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Microarray platforms--comparisons and contrasts.

机译:微阵列平台-比较和对比

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摘要

In the relatively few years since their inception, DNA microarrays and Affymetrix GeneChips have gained increasing use and acceptance in the study of genetic and cellular processes. This is evident from the rising number of published literature citing microarrays each year. With time, gene chips and microarrays have matured into complex technologies as biologists have teamed with applied mathematicians and statisticians to increase the rigor of experimentation and address the problems associated with the manipulation of large data sets. Several complementary microarray technologies for measuring gene expression are now routinely employed. This review will discuss the similarities and differences among these technologies and cover recent efforts to integrate data from cross-platform comparative studies.
机译:自从成立以来的相对几年中,DNA微阵列和Affymetrix GeneChips在遗传和细胞过程的研究中得到越来越多的使用和接受。从每年引用微阵列的已发表文献数量的增加中可以明显看出这一点。随着时间的推移,由于生物学家与应用数学家和统计学家合作,基因芯片和微阵列已经发展成为复杂的技术,以增加实验的严格性并解决与处理大数据集相关的问题。现在常规使用几种互补的微阵列技术来测量基因表达。这篇综述将讨论这些技术之间的异同,并涵盖整合跨平台比较研究数据的最新努力。

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