• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacogenomics >Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment
【24h】

Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment

机译：根深蒂固：低密度脂蛋白胆固醇水平的遗传易感性与对他汀类药物治疗的低密度脂蛋白胆固醇反应减少有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims: To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response. Methods: We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia. Results: Lead SNPs for APOE, SORT1 and NPC1L1 were associated with a decreased LDL-c response to statin treatment, as was overall genetic predisposition for increased LDL-c levels as quantified with 59 SNPs, with a 5.4% smaller statin response per standard deviation increase in genetically raised LDL-c levels. Conclusion: Genetic predisposition for increased LDL-c level may decrease efficacy of statin therapy.
机译：目的：利用先前报道的低密度脂蛋白胆固醇（LDL-c）水平的铅单核苷酸多态性（SNPs），寻找对他汀类药物反应重要的其他基因座，并检查对LDL-c水平的遗传易感性是否与他汀类药物反应不同。方法：我们结合了全球脂质遗传学和他汀类药物治疗联盟的基因组研究，总结了其对59种LDL-c SNP对他汀类药物反应的影响。结果：APOE，SORT1和NPC1L1的铅单核苷酸多态性与对他汀类药物治疗的LDL-c应答降低有关，LDL-c水平升高的总体遗传易感性由59个SNPs量化，每个标准差的他汀类药物应答降低5.4％基因升高的LDL-c水平增加。结论：LDL-c水平升高的遗传易感性可能会降低他汀类药物治疗的疗效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号