Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor

HoT.-Y.; TangN.-Y.; HsiangC.-Y.; HsiehC.-L.

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Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor

机译：钩藤钩藤和钩藤碱可通过IL-1β和脑源性神经营养因子改善海藻酸诱导的癫痫发作

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Uncaria rhynchophylla (UR) has been used for the treatment of convulsions and epilepsy in traditional Chinese medicine. This study reported the major anti-convulsive signaling pathways and effective targets of UR and rhynchophylline (RP) using genomic and immunohistochemical studies. Epileptic seizure model was established by intraperitoneal injection of kainic acid (KA) in rats. Electroencephalogram and electromyogram recordings indicated that UR and RP improved KA-induced epileptic seizures. Toll-like receptor (TLR) and neurotrophin signaling pathways were regulated by UR in both cortex and hippocampus of KA-treated rats. KA upregulated the expression levels of interleukin-1β (IL-1β) and brain-derived neurotrophin factor (BDNF), which were involved in TLR and neurotrophin signaling pathways, respectively. However, UR and RP downregulated the KA-induced IL-1β and BDNF gene expressions. Our findings suggested that UR and RP exhibited anti-convulsive effects in KA-induced rats via the regulation of TLR and neurotrophin signaling pathways, and the subsequent inhibition of IL-1β and BDNF gene expressions.

机译：钩藤（Uncaria rhynchophylla，UR）已被用于中药的惊厥和癫痫治疗。这项研究使用基因组和免疫组化研究报告了主要的抗惊厥信号传导途径和UR和乙酰胆碱（RP）的有效靶标。通过腹腔注射海藻酸（KA）建立癫痫性癫痫发作模型。脑电图和肌电图记录表明，UR和RP可改善KA诱发的癫痫发作。在KA处理的大鼠的皮层和海马中，UR调节Toll样受体（TLR）和神经营养蛋白信号通路。 KA分别上调了TLR和神经营养因子信号通路中的白介素-1β（IL-1β）和脑源性神经营养因子（BDNF）的表达水平。然而，UR和RP下调了KA诱导的IL-1β和BDNF基因表达。我们的研究结果表明，UR和RP通过调节TLR和神经营养蛋白信号传导通路以及随后抑制IL-1β和BDNF基因表达，在KA诱导的大鼠中表现出抗惊厥作用。

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《Phytomedicine :》 |2014年第6期|共8页
作者
HoT.-Y.; TangN.-Y.; HsiangC.-Y.; HsiehC.-L.;
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正文语种 eng
中图分类植物学;
关键词
Brain-derived neurotrophic factor; Epileptic seizure; Interleukin-1β; Rhynchophylline; Uncaria rhynchophylla;

机译：脑源性神经营养因子;癫痫发作;白介素-1β;支气管茶碱;钩藤;

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专利

1. Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor [J] . HoT.-Y., TangN.-Y., HsiangC.-Y., Phytomedicine : . 2014,第6期

机译：钩藤钩藤和钩藤碱可通过IL-1β和脑源性神经营养因子改善海藻酸诱导的癫痫发作
2. Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. [J] . Lin YW, Hsieh CL Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2011,第2期

机译：口腔钩藤（UR）减少海藻酸诱导的癫痫发作和神经元死亡，同时减轻大鼠胶质细胞增殖和S100B蛋白。
3. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. [J] . Katoh Semba-R, Takeuchi IK, Inaguma Y, Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 1999,第1期

机译：海藻酸诱导的癫痫发作后，大鼠脑中的脑源性神经营养因子，神经生长和Neurotrophin-3选择区域。
4. Effect of transplantation of bone marrow mesenchymal stem cells on the expression of nerve growth factor and brain-derived neurotrophic factor in rats after sciatic nerve crush injury [C] . Hua Xin, Guang Yang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：骨髓间充质干细胞移植对坐骨神经挤压伤大鼠神经生长因子和脑源性神经营养因子表达的影响
5. Improving the Ability of the MMPI-2-RF to Discriminate between Psychogenic Non-epileptic Seizures and Epileptic Seizures. [D] . Wershba, Rebecca E. 2013

机译：提高MMPI-2-RF区分精神性非癫痫性发作和癫痫性癫痫发作的能力。
6. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats [O] . Nou-Ying Tang, Yi-Wen Lin, Tin-Yun Ho, 2017

机译：长期摄入钩藤钩藤降低海藻酸诱导的癫痫发作大鼠的S100B和RAGE蛋白水平。
7. Neuroprotective Effect of Uncaria rhynchophylla in Kainic Acid-Induced Epileptic Seizures by Modulating Hippocampal Mossy Fiber Sprouting, Neuron Survival, Astrocyte Proliferation, and S100B Expression [O] . Liu, Chung-Hsiang, Lin, Yi-Wen, Tang, Nou-Ying, 2012

机译：调节海马苔藓纤维发芽，神经元存活，星形胶质细胞增殖和S100B表达的花胶藤藻对海藻酸诱导的癫痫发作的神经保护作用。

Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor

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