Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathway

Kim Ye-Seul; Choi Kyung-Chul; Hwang Kyung-A

首页> 外文期刊>Phytomedicine : >Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathway

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Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathway

机译：金雀异黄素抑制雌激素化学物质通过雌激素受体途径激活的BG-1卵巢癌细胞的上皮-间质转化和迁移效率，并下调TGF-β信号通路

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Background: Epithelial-mesenchymal transition (EMT), which is activated by 17 beta-estradiol (E2) in estrogen-responsive cancers, is an important process in tumor migration or progression. As typical endocrine disrupting chemicals (EDCs), bisphenol A (BPA) and nonylphenol (NP) have a potential to promote EMT and migration of estrogen-responsive cancers. On the contrary, genistein (GEN) as a phytoestrogen is known to have chemopreventive effects in diverse cancers.

机译：背景：上皮-间质转化（EMT）在雌激素反应性癌症中被17β-雌二醇（E2）激活，是肿瘤迁移或进展的重要过程。作为典型的破坏内分泌的化学物质（EDC），双酚A（BPA）和壬基酚（NP）具有促进EMT和雌激素反应性癌症迁移的潜力。相反，染料木黄酮（GENistein）作为植物雌激素在多种癌症中具有化学预防作用。

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《Phytomedicine :》 |2015年第11期|共7页
作者
Kim Ye-Seul; Choi Kyung-Chul; Hwang Kyung-A;
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正文语种 eng
中图分类植物学;
关键词
Cancer migration; EMT; Genistein; Ovarian cancer;

机译：癌症迁移;EMT;Genistein;卵巢癌;

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1. Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathway [J] . Kim Ye-Seul, Choi Kyung-Chul, Hwang Kyung-A Phytomedicine : . 2015,第11期

机译：金雀异黄素抑制雌激素化学物质通过雌激素受体途径激活的BG-1卵巢癌细胞的上皮-间质转化和迁移效率，并下调TGF-β信号通路
2. Benzophenone-1 stimulated the growth of BG-1 ovarian cancer cells by cell cycle regulation via an estrogen receptor alpha-mediated signaling pathway in cellular and xenograft mouse models [J] . ParkM.-A., HwangK.-A., LeeH.-R., Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2013,第Null期

机译：苯甲酮-1通过雌激素受体α介导的信号通路在细胞和异种移植小鼠模型中通过细胞周期调控刺激BG-1卵巢癌细胞的生长
3. Effect of of benzophenone-1 and octylphenol on the regulation of epithelial-mesenchymal transition via an estrogen receptor dependent pathway in estrogen receptor expressing ovarian cancer cells [J] . Shin Sam, Go Ryeo-Eun, Kim Cho-Won, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2016,第Null期

机译：二苯甲酮-1和辛基酚对雌激素受体表达卵巢癌细胞中雌激素受体依赖性途径对上皮-间质转化的调节作用
4. Modeling estrogen receptor pathways in breast cancer using an Artificial Neural Networks based inference approach [C] . Dhondalay Gopal K, Lemetre Christophe, Ball Graham R Biomedical and Health Informatics (BHI), 2012 IEEE-EMBS International Conference on . 2012

机译：使用基于人工神经网络的推理方法对乳腺癌中的雌激素受体途径进行建模
5. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via inhibition of the phosphoinositide 3-kinases pathway [D] . Moore, Robert L. 2011

机译：SIRT1通过抑制磷酸肌醇3激酶途径抑制雌激素信号传导，配体独立的雌激素受体α介导的转录和乳腺癌细胞的增殖
6. Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells [O] . Jie Yuan, Manran Liu, Li Yang, 2015

机译：他莫昔芬抗性乳腺癌细胞上皮-间质转化表型的获得：G蛋白偶联雌激素受体通过肿瘤相关的成纤维细胞衍生纤连蛋白和β1-整合素信号通路介导他莫昔芬抗性的新作用
7. Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells [O] . 2015

机译：他莫昔芬抗性乳腺癌细胞上皮-间质转化表型的获得：G蛋白偶联雌激素受体通过肿瘤相关的成纤维细胞衍生纤连蛋白和β1-整合素信号通路介导他莫昔芬抗性的新作用
8. Characterization of an ICII82, 780-Induced, Estrogen Receptor (ER)-beta Mediated Apoptotic Pathway in Prostate Cancer Cells and Establishment of (ER)- beta-Regulated Electrophile-Processing Phase II Enzyme Downregulation as a Promotional Factor in Human Prostatic Carcinogenesis [R] . Ho, S. 2001

机译：表征ICII82,780诱导的雌激素受体（ER）-β介导的前列腺癌细胞凋亡途径和建立（ER） - β调节的亲电子处理II期酶下调作为人类前列腺癌发生的促进因子。

Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathway

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