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首页> 外文期刊>Biomaterials >Polyetheretherketone--cytotoxicity and mutagenicity in vitro.
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Polyetheretherketone--cytotoxicity and mutagenicity in vitro.

机译：聚醚醚酮-体外细胞毒性和致突变性。

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摘要

The results of the incubation of polyetheretherketone (PEEK) fibre material with seven different genotype variants of salmonella bacterium showed with and without an external metabolic activation system (S9) with no mutagenic or cytotoxic activity of the test material. In the so-called "plate incorporation test" in which the PEEK raw material is finely cut and applied direct to the agar plate without the addition of solvent there was, as expected, no evidence of cytotoxic or mutagenic effects. In the HPRT test there was a significant increase in the number of mutants per dish, both after addition of N-acetylaminofluorene and N-methyl-N'-nitro-N-nitrosoguanidine (with and without an external metabolic activation system = +S9), but not after treatment of the cells with PEEK-DMSO-eluate. This means that the PEEK material under study did not release any substances that cause V79 cells to mutate. The investigation of the toxic reaction on the material under study revealed that the number of surviving colonies per 10(5) surviving cells lay within the range of or below the solvent control even in the presence of high PEEK concentrations (5.0 microg/ml). Therefore, in summary, the study produced no evidence of cell damage caused by PEEK.
机译：聚醚醚酮（PEEK）纤维材料与沙门氏菌7种不同基因型变体的孵育结果显示，有或没有外部代谢激活系统（S9），测试材料均无诱变或细胞毒性。在所谓的“板结合试验”中，将PEEK原料进行了精细切割，并直接添加到琼脂板上，而没有添加溶剂，正如所预期的，没有任何细胞毒性或诱变作用的证据。在HPRT测试中，添加N-乙酰氨基芴和N-甲基-N'-硝基-N-亚硝基胍后（带有或不带有外部代谢激活系统= + S9），每个培养皿中的突变体数量均显着增加。 ，但在用PEEK-DMSO洗脱液处理细胞后未进行。这意味着所研究的PEEK材料不会释放任何导致V79细胞突变的物质。对所研究材料的毒性反应的研究表明，即使存在高PEEK浓度（5.0 microg / ml），每10（5）个存活细胞的存活菌落数仍在溶剂控制范围内或低于溶剂控制范围。因此，总而言之，该研究未产生由PEEK引起的细胞损伤的证据。

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