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pyewacket, a new zebrafish fin pigment pattern mutant

机译:pyewacket,一种新的斑马鱼鳍色素图案突变体

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Many mutants that disrupt zebrafish embryonic pigment pattern have been isolated, and subsequent cloning of the mutated genes causing these phenotypes has contributed to our understanding of pigment cell development. However, few mutants have been identified that specifically affect development of the adult pigment pattern. Through a mutant screen for adult pigment pattern phenotypes, we identified pyewacket (pye), a novel zebrafish mutant in which development of the adult caudal fin pigment pattern is aberrant. Specifically, pye mutants have fin melanocyte pigment pattern defects and fewer xanthophores than wild-type fins. We mapped pye to an interval where a single gene, the zebrafish ortholog of the human gene DHRSX, is present. pye will be an informative mutant for understanding how xanthophores and melanocytes interact to form the pigment pattern of the adult zebrafish fin.
机译:已经分离了许多破坏斑马鱼胚胎色素图谱的突变体,随后克隆导致这些表型的突变基因有助于我们对色素细胞发育的理解。但是,几乎没有发现突变体会特别影响成年色素图案的发育。通过针对成人色素图案表型的突变体筛选,我们鉴定了pyewacket(pye),一种新型的斑马鱼突变体,其中成人尾鳍色素图案的发育异常。具体而言,派伊突变体具有鳍黑素细胞色素模式缺陷,并且比野生型鳍具有更少的黄体。我们将pye映射到一个存在人类基因DHRSX的斑马鱼直系同源基因的区间。 pye将是一个信息丰富的突变体,用于了解黄体细胞和黑素细胞如何相互作用以形成成年斑马鱼鳍的色素图案。

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