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首页> 外文期刊>Pigment cell research >Color reversion of the albino medaka fish associated with spontaneous somatic excision of the Tol-1 transposable element from the tyrosinase gene
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Color reversion of the albino medaka fish associated with spontaneous somatic excision of the Tol-1 transposable element from the tyrosinase gene

机译：与酪氨酸酶基因自发体细胞切除Tol-1转座因子相关的白化鱼变色

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摘要

The medaka fish albino mutant, i(1) is one of the Tomita collection of medaka pigmentation mutants which exhibits a complete albino phenotype, because of inactivation of the tyrosinase gene due to insertion of a transposable element, Tol-1. Recently, mosaic black-pigmented i(1) medaka fish have arisen in one of our laboratory breeding populations. Their pigmented cells have been observed in all of the tissues, including the eye and skin, in which melanin is detectable in the wild type. In this study, we analyzed the tyrosinase gene of revertants and showed Tol-1 to have been precisely excised from the gene, suggesting a causal relationship. Mosaic patterns of pigmentation indicate spontaneous somatic excision of the element from the tyrosinase gene. To our knowledge, this is the first transposable element with somatic excision activity demonstrated phenotypically in vertebrates. The pattern of pigmentation in mosaic revertants indicates frequencies of melanin pigments to be consistent with the numbers of melanophores per unit area of body sites, such as the eyes, head and dorsal trunk.
机译：medaka鱼类白化变种i（1）是medaka色素沉着突变体的Tomita集合之一，由于酪氨酸酶基因由于转座因子Tol-1的插入而失活，因此具有完整的白化表型。最近，在我们的一个实验室繁殖种群中出现了镶嵌黑色色素的i（1）medaka鱼。在所有组织（包括眼睛和皮肤）中都观察到了它们的色素细胞，在野生型中可检测到黑色素。在这项研究中，我们分析了回复子的酪氨酸酶基因，并显示Tol-1已从该基因中精确切除，表明存在因果关系。色素沉着的马赛克图样表明从酪氨酸酶基因中自然去除了该元素。据我们所知，这是在脊椎动物中表型表现出的第一个具有体细胞切除活性的转座因子。镶嵌回复剂中的色素沉着模式表明黑色素色素的频率与每单位身体部位（例如眼睛，头部和背部躯干）的黑色素细胞数目一致。

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