Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes

Joshi PG; Nair N; Begum G; Joshi NB; Sinkar VP; Vora S

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Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes

机译：黑色素细胞与角质形成细胞的相互作用诱导钙信号传导和黑色素转移至角质形成细胞

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Physical contact between melanocytes and keratinocytes is a prerequisite for melanosome transfer to occur, but cellular signals induced during or after contact are not fully understood. Herein, it is shown that interactions between melanocyte and keratinocyte plasma membranes induced a transient intracellular calcium signal in keratinocytes that was required for pigment transfer. This intracellular calcium signal occurred due to release of calcium from intracellular stores. Pigment transfer observed in melanocyte-keratinocyte co-cultures was inhibited when intracellular calcium in keratinocytes was chelated. We propose that a 'ligand-receptor' type interaction exists between melanocytes and keratinocytes that triggers intracellular calcium signalling in keratinocytes and mediates melanin transfer.

机译：黑色素细胞和角质形成细胞之间的物理接触是黑素体转移发生的先决条件，但在接触过程中或接触后诱导的细胞信号尚不完全清楚。在此，表明黑素细胞和角质形成细胞质膜之间的相互作用在色素转移中诱导了角质形成细胞中的瞬时细胞内钙信号。这种细胞内钙信号的发生是由于钙从细胞内存储中释放出来的。当螯合角质形成细胞中的细胞内钙时，黑素细胞-角质形成细胞共培养物中观察到的色素转移被抑制。我们建议在黑色素细胞和角质形成细胞之间存在“配体-受体”型相互作用，从而触发角质形成细胞中的细胞内钙信号传导并介导黑色素转移。

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《Pigment cell research》 |2007年第5期|共5页
作者
Joshi PG; Nair N; Begum G; Joshi NB; Sinkar VP; Vora S;
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正文语种 eng
中图分类细胞形态学;
关键词
melanocyte; keratinocyte; intracellular calcium; melanin transfer; MELANOSOME TRANSFER; INTRACELLULAR CALCIUM; E-CADHERIN; IN-VITRO; CA2+; RECEPTOR; ADHESION; CONTACT; GROWTH; CELLS;

机译：黑色素细胞;角质形成细胞;细胞内钙;黑色素转移;黑色素转移;细胞内钙;E-钙粘蛋白;体外;CA2 +;受体;粘附;接触;生长;细胞;

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专利

1. Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes [J] . Joshi PG, Nair N, Begum G, Pigment cell research . 2007,第5期

机译：黑色素细胞与角质形成细胞的相互作用诱导钙信号传导和黑色素转移至角质形成细胞
2. An intact actin-containing cytoskeleton is required for capacitative calcium entry, but not for ATP-induced calcium-mediated cell signaling in cultured human keratinocytes [J] . Timo Korkiamaki, Heli Yla-Outinen, Jussi Koivunen, Medical science monitor : . 2003,第5期

机译：电容性钙进入需要完整的含肌动蛋白的细胞骨架，但培养的人角质形成细胞中ATP诱导的钙介导的细胞信号传导则不需要
3. Autocrine Extracellular Signal-regulated Kinase Activation in Normal Human Keratinocytes is not Interrupted by Calcium Triggering and is Involved in the Control of Cell Cycle at the Early Stage of Calcium-induced Differentiation [J] . Park Geon Tae, Kim Hyo-Youn, Kim Eun-Kyoung, Journal of Korean medical science. . 2007,第2期

机译：正常人角质形成细胞中的自分泌细胞外信号调节的激酶激活不会被钙触发中断，并且参与钙诱导的分化的早期细胞周期的控制。
4. Optimizing an endocytosis assay for the characterization of melanin uptake and processing by keratinocytes [C] . Correia M.S., Tarafder A.K., lannone L, Society for Pigment Cell Research., Meeting. . 2012

机译：优化内吞作用测定，以表征黑色素摄取和异畸形细胞加工
5. S100 proteins as calcium signaling mediators and transglutaminase substrates in keratinocyte biology. [D] . Ruse, Monica. 2003

机译：S100蛋白在角质形成细胞生物学中作为钙信号传导介质和转谷氨酰胺酶的底物。
6. Autocrine Extracellular Signal-regulated Kinase Activation in Normal Human Keratinocytes is not Interrupted by Calcium Triggering and is Involved in the Control of Cell Cycle at the Early Stage of Calcium-induced Differentiation [O] . Geon Tae Park, Hyo-Youn Kim, Eun-Kyoung Kim, 2007

机译：正常人角质形成细胞中的自分泌细胞外信号调节的激酶激活不被钙触发所干扰并且参与钙诱导的分化的早期细胞周期的控制。
7. Epidermal Melanin Units Melanocyte-Keratinocyte Interactions [O] . WALTER C Quevedo 1972

机译：表皮黑色素单位黑素细胞 - 角质形成细胞相互作用

Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes

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