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首页> 外文期刊>Pigment cell research >Myosins in melanocytes: to move or not to move?
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Myosins in melanocytes: to move or not to move?

机译：黑色素细胞中的肌球蛋白：移动还是不移动？

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摘要

The actin network has been implicated in the intracellular transport and positioning of the melanosomes, organelles that are specialized in the biosynthesis and the storage of melanin. It contributes also to molecular mechanisms that underlie the intracellular membrane dynamics and thereby can control the biogenesis of melanosomes. Two mechanisms for actin-based movements have been identified: one is dependent on the motors associated to actin namely the myosins; the other is dependent on actin polymerization. This review will focus on to the role of the actin cytoskeleton and myosins in the transport and in the biogenesis of melanosomes. Myosins involved in membrane traffic are largely seen as transporters of organelles or membrane vesicles containing cargos along the actin networks. Yet increasing evidence suggests that some of the myosins contribute to the dynamics of internal membrane by using other mechanisms. The role of the myosins and the different molecular mechanisms by which they contribute or may contribute to the distribution, the movement and the biogenesis of the melanosomes in epidermal melanocytes and retinal pigmented epithelial (RPE) cells will be discussed.
机译：肌动蛋白网络与黑素体，专门从事生物合成和黑色素存储的细胞器的细胞内运输和定位有关。它还有助于细胞内膜动力学基础的分子机制，从而可以控制黑素体的生物发生。已经确定了两种基于肌动蛋白的运动机制：一种依赖于与肌动蛋白相关的马达，即肌球蛋白;另一种依赖于肌动蛋白。另一个取决于肌动蛋白聚合。这项审查将侧重于肌动蛋白细胞骨架和肌球蛋白在黑素体的运输和生物发生中的作用。膜运输中涉及的肌球蛋白在很大程度上被认为是沿肌动蛋白网络运输的细胞器或膜囊泡。然而，越来越多的证据表明，某些肌球蛋白通过使用其他机制有助于内膜的动力学。将讨论肌球蛋白的作用以及它们通过或可能有助于表皮黑素细胞和视网膜色素上皮（RPE）细胞中黑素体的分布，运动和生物发生的不同分子机制。

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