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The genetics of generalized vitiligo and associated autoimmune diseases

机译：广泛性白癜风的遗传学和相关的自身免疫性疾病

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Vitiligo is an acquired disorder in which patches of depigmented skin and often overlying hair, and mucous membranes, are the result of progressive autoimmune loss of melanocytes from the involved areas. Considered the most common pigmentary disorder, vitiligo involves complex interaction of environmental and genetic factors that ultimately contribute to melanocyte destruction, resulting in the characteristic depigmented lesions. In the past few years, studies of the genetic epidemiology of vitiligo have led to the recognition that generalized vitiligo is part of a broader autoimmune disease diathesis. Attempts to identify genes involved in susceptibility to generalized vitiligo have involved gene expression studies, genetic association studies of candidate genes, and genome-wide linkage analyses to discover new genes. These studies have begun to yield results that shed light on the mechanisms of vitiligo pathogenesis. It is anticipated that the discovery of biological pathways of vitilligo pathogenesis will provide novel targets for future approaches to the treatment and prevention of vitiligo and its associated autoimmune diseases.
机译：白癜风是一种获得性疾病，其中色素沉着的皮肤（通常覆盖在头发上）和粘膜斑块是受累区域黑色素细胞进行自身免疫性逐渐丧失的结果。白癜风被认为是最常见的色素性疾病，涉及环境和遗传因素的复杂相互作用，最终导致黑素细胞破坏，从而导致特征性的色素沉着病变。在过去的几年中，对白癜风遗传流行病学的研究已导致人们认识到，广义的白癜风是更广泛的自身免疫性疾病素质的一部分。试图鉴定涉及广泛性白癜风易感性的基因涉及基因表达研究，候选基因的遗传关联研究以及全基因组连锁分析以发现新基因。这些研究已开始产生结果，阐明了白癜风发病机理。可以预料的是，小玻璃藻发病机理的生物学途径的发现将为治疗和预防白癜风及其相关的自身免疫性疾病的未来方法提供新的靶标。

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