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首页> 外文期刊>Pigment cell research >Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation
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Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation

机译：Ednrb2定向细胞向背外侧神经c通路迁移并促进黑素细胞分化

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摘要

Endothelin receptors B (Ednrb) are involved in the development of the enteric and melanocytic lineages, which originate from neural crest cells (NCCs). In mice, trunk NCCs and their derivatives express only one Ednrb. In quail, trunk NCCs express two Ednrb: Ednrb and Ednrb2. Quail Ednrb is expressed in NCCs migrating along the ventral pathway, which gives rise to the peripheral nervous system, including enteric ganglia. Ednrb2 is upregulated in NCCs before these cells enter the dorsolateral pathway. The NCCs migrating along the dorsolateral pathway are melanocyte precursors. We analyzed the in vitro differentiation and in ovo migration of mouse embryonic stem (ES) cells expressing and not expressing Ednrb2. We generated a series of transfected ES cell lines expressing Ednrb2. This receptor, like Ednrb, oriented genuine ES cells towards melanocyte lineage differentiation in vitro. The in ovo migration of Ednrb2-expressing ES cells was massively oriented towards the dorsolateral pathway, unlike that of WT or Ednrb-expressing ES cells. Thus, Ednrb2 is involved in melanoblast differentiation and migration.
机译：内皮素B（Ednrb）参与肠和黑素细胞谱系的发展，这些谱系起源于神经rest细胞（NCC）。在小鼠中，躯干NCC及其衍生物仅表达一种Ednrb。在鹌鹑中，主干NCC表示两个Ednrb：Ednrb和Ednrb2。鹌鹑Ednrb在沿腹侧途径迁移的NCC中表达，从而引起周围神经系统，包括肠神经节。在这些细胞进入背外侧途径之前，Ednrb2在NCC中被上调。沿背外侧途径迁移的NCC是黑色素细胞的前体。我们分析了表达和不表达Ednrb2的小鼠胚胎干（ES）细胞的体外分化和卵内迁移。我们生成了一系列表达Ednrb2的转染ES细胞系。像Ednrb一样，这种受体在体外将真正的ES细胞导向黑色素细胞谱系分化。与表达WT或表达Ednrb的ES细胞不同，表达Ednrb2的ES细胞的卵内迁移主要朝向背外侧途径。因此，Ednrb2参与黑素细胞的分化和迁移。

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