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Melanoma inhibitory activity (MIA): an important molecule in melanoma development and progression

机译：黑色素瘤抑制活性（MIA）：黑色素瘤发展和进程中的重要分子

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摘要

Cutaneous malignant melanoma is the leading cause of skin cancer death in industrialized countries. Melanoma development and progression are well defined by clinical and histopathological aspects; however, detailed analysis of molecular changes is still ongoing. The protein MIA, which is strongly expressed in melanoma cells but not in melanocytes, is likely to represent a key molecule regulating melanoma progression. Consistent with this, several in vitro and in vivo model systems indicate a direct involvement of MIA in melanoma migration and invasion, with recent studies suggesting a central role for MIA in early melanoma development by regulating important melanoma-related pathways and molecules. The latest developments in MIA research are summarized in this review, which describes recently published data related to the MIA protein structure and function, the role of MIA in melanoma development and progression, and the regulation of MIA expression. Furthermore, newly discovered MIA-homologous genes are discussed.
机译：皮肤恶性黑色素瘤是工业化国家皮肤癌死亡的主要原因。黑色素瘤的发生和发展在临床和组织病理学方面都有很好的定义。但是，分子变化的详细分析仍在进行中。 MIA蛋白在黑色素瘤细胞中强烈表达，但在黑色素细胞中不表达，很可能代表了调节黑色素瘤进展的关键分子。与此相一致，一些体外和体内模型系统表明MIA直接参与了黑色素瘤的迁移和侵袭，最近的研究表明，MIA通过调节重要的黑色素瘤相关途径和分子，在黑色素瘤的早期发展中起着核心作用。这篇综述总结了MIA研究的最新进展，它描述了最近发表的与MIA蛋白结构和功能，MIA在黑素瘤发展和进展中的作用以及MIA表达调控有关的数据。此外，讨论了新发现的MIA同源基因。

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