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首页> 外文期刊>Pigment cell research >Decreased expression of Apaf-1 with progression of melanoma
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Decreased expression of Apaf-1 with progression of melanoma

机译：黑素瘤进展导致Apaf-1表达降低

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摘要

Defects in apoptotic system may contribute in the pathogenesis and resistance of malignant melanoma cells to chemotherapy. Apoptotic protease-activating factor-1 (Apaf-1) is a cell death effector that acts with cytochrome c and caspase-9 to mediate apoptosis. Recently it was shown that metastatic melanomas often lose Apaf-1 and are concomitantly resistant to apoptosis. It is not known, however, whether Apaf-1 protein is lost during melanoma progression from localized to metastatic tumor. To this end, we evaluated Apaf-1 protein expression by immunohistochemistry in 10 cases of human nevi, 11 melanomas in situ, 26 primary melanomas and 15 metastases. Significant decreases in Apaf-1 expression was observed when comparing nevi and melanomas (chi-square = 33.719; P < 0.0001). Moreover, primary melanomas with greater tumor thickness showed lesser expression of Apaf-1 (chi-square = 16.182; P < 0.003). Intriguingly, we were unable to detect Apaf-1 expression in lesions of metastatic melanomas. These data demonstrated that there is an inverse correlation between Apaf-1 expression and pathologic stage of melanoma. This suggests that the decreased expression of Apaf-1 seen in correlation with melanoma progression renders melanoma more resistant to chemotherapy.
机译：凋亡系统中的缺陷可能有助于恶性黑色素瘤细胞的发病机理和对化疗的耐药性。凋亡蛋白酶激活因子1（Apaf-1）是一种细胞死亡效应子，与细胞色素c和caspase-9相互作用介导凋亡。最近显示，转移性黑色素瘤经常丢失Apaf-1，并同时对细胞凋亡具有抗性。但是，尚不知道在黑色素瘤从局限性转移到转移性肿瘤的过程中，Apaf-1蛋白是否丢失。为此，我们通过免疫组织化学评估了10例人类痣，11例原位黑素瘤，26例原发性黑素瘤和15处转移瘤中Apaf-1蛋白的表达。比较痣和黑色素瘤时，Apaf-1表达显着下降（卡方= 33.719; P <0.0001）。而且，具有更大肿瘤厚度的原发性黑素瘤显示了Apaf-1的较少表达（卡方= 16.182; P <0.003）。有趣的是，我们无法在转移性黑色素瘤的病变中检测到Apaf-1表达。这些数据表明，Apaf-1表达与黑色素瘤的病理分期之间呈负相关。这表明与黑素瘤进展相关的Apaf-1表达降低使黑素瘤对化学疗法更具抵抗力。

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