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首页> 外文期刊>Pigment cell research >Association of HLA Class I Antigens and HLA Class II Alleles with Vitiligo in a Turkish Population
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Association of HLA Class I Antigens and HLA Class II Alleles with Vitiligo in a Turkish Population

机译：HLA I类抗原和HLA II类等位基因与白癜风在土耳其人口中的关联

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As is the case with many other autoimmune diseases, there is an association between vitiligo and HLA complex. HLA subtypes vary with racial/ethnic background. The purpose of this study was to determine which HLA class I antigens and HLA class II alleles are associated with Turkish vitiligo patients. Forty-one patients with vitiligo and 61 healthy control subjects were typed for HLA class II alleles. Thirty-three out of 41 patients with vitiligo and 100 healthy transplant donors were typed for HLA class I antigens. HLA DNA typing was performed by polymerase chain reaction/sequence specific primer method for class II. HLA typing for class I was performed by serological method. The frequency of HLA DRB1~*03 was 0.6340 in patients compared to 0.2950 in controls (P = 0.0014). The frequency of HLA DRB1~*04 was found to be 0.6830 in patients compared to 0.2950 in controls (P = 0.00026). The allele HLA DRB1~*07 was present in 0.390 of patients compared to 0.0820 of the controls (P = 0.0004). A preventive antigen for the manifestation of vitiligo has not been identified in this study. Our findings suggest that DRB1~*03, DRB1~*04 and DRB1~*07 alleles are genetic markers for general susceptibility to vitiligo in a Turkish population.
机译：与许多其他自身免疫性疾病一样，白癜风和HLA复合体之间也存在关联。 HLA亚型随种族/种族背景而变化。这项研究的目的是确定哪些HLA I类抗原和HLA II类等位基因与土耳其白癜风患者相关。对41名白癜风患者和61名健康对照受试者进行HLA II类等位基因分型。在41名白癜风患者中，有33名和100名健康的移植供者针对HLA I类抗原进行了分型。通过II类的聚合酶链反应/序列特异性引物方法进行HLA DNA分型。通过血清学方法对I类进行HLA分型。患者的HLA DRB1〜* 03频率为0.6340，而对照组为0.2950（P = 0.0014）。患者的HLA DRB1〜* 04频率为0.6830，而对照组为0.2950（P = 0.00026）。 0.390的患者中存在等位基因HLA DRB1〜* 07，而对照组为0.0820（P = 0.0004）。这项研究中尚未鉴定出预防白癜风的抗原。我们的发现表明，DRB1〜* 03，DRB1〜* 04和DRB1〜* 07等位基因是土耳其人群对白癜风普遍易感性的遗传标记。

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