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首页> 外文期刊>Pigment cell research >Unusual Leucophore-like Cells Specifically Appear in the Lineage of Melanophores in the Periodic Albino Mutant of Xenopus laevis
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Unusual Leucophore-like Cells Specifically Appear in the Lineage of Melanophores in the Periodic Albino Mutant of Xenopus laevis

机译：Xenopus laevis的周期性白化突变体的黑素细胞谱系中特别出现不寻常的leucophore样细胞。

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摘要

In the periodic albino mutant (ap/ap) of Xenopus laevis, peculiar leucophore-like cells appear in the skins of tadpoles and froglets, whereas no such cells are observed in the wild-type (+/+). These leucophore-like cells are unusual in (1) appearing white, but not iridescent, under incident light, (2) emitting green fluorescence under blue light, (3) exhibiting pigment dispersion in the presence of a-melanocyte stimulating hormone (aMSH), and (4) containing an abundance of bizarre-shaped, reflecting platelet-like organelles. In this study, the developmental and ultrastructural characteristics of these leucophore-like cells were compared with melanophores, iridophores and xanthophores, utilizing fluorescence stereomicroscopy, and light and electron microscopy. Staining with methylene blue, exposure to aMSH, and culture of neural crest cells was also performed to clarify the pigment cell type. The results obtained clearly indicate that: (1) the leucophore-like cells in the mutant are different from melanophores, iridophores and xanthophores, (2) the leucophore-like cells are essentially similar to melanophores of the wild-type with respect to their localization in the skin and manner of response to aMSH, (3) the leucophore-like cells contain many premelanosomes that are observed in developing melanophores, and (4) mosaic pigment cells containing both melanosomes specific to mutant melanophores and peculiar reflecting platelet-like organelles are observed in the mutant tadpoles. These findings strongly suggest that the leucophore-like cells in the periodic albino mutant are derived from the melanophore lineage, which provides some insight into the origin of brightly colored pigment cells in lower vertebrates.
机译：在非洲爪蟾的周期性白化突变体（ap / ap）中，p和小蛙的皮肤中出现了奇异的白细胞样细胞，而在野生型（+ / +）中未观察到此类细胞。这些无色细胞样细胞在（1）在入射光下呈白色但不呈虹彩，（2）在蓝光下发出绿色荧光，（3）在α-黑素细胞刺激激素（aMSH）存在下表现出色素分散性方面很不寻常。 （4）含有大量奇异形的反射性血小板样细胞器。在这项研究中，利用荧光立体显微镜以及光和电子显微镜，将这些无色细胞样细胞的发育和超微结构特征与黑素细胞，虹膜细胞和黄体细胞进行了比较。还进行了亚甲基蓝染色，暴露于aMSH以及培养神经cells细胞以阐明色素细胞类型。获得的结果清楚地表明：（1）突变体中的类似隐喻的细胞不同于黑素细胞，虹膜和黄原细胞;（2）隐喻样细胞的定位在本质上与野生型的黑素细胞相似。在皮肤和对aMSH的反应方式方面，（3）隐色团样细胞含有许多在发育中的黑素团中观察到的黑素体，（4）镶嵌色素细胞同时含有对突变黑素团特异的黑素体和特殊的反射性血小板样细胞器。在突变t中观察到。这些发现强烈表明，周期性白化突变体中的无色细胞样细胞源于黑色素细胞谱系，这为低等脊椎动物中颜色鲜艳的色素细胞的起源提供了一些见识。

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