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首页> 外文期刊>Placenta >Activin A and inhibin B in extra-embryonic coelomic and amniotic fluids, and maternal serum in early pregnancy.
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Activin A and inhibin B in extra-embryonic coelomic and amniotic fluids, and maternal serum in early pregnancy.

机译：胚胎外腔积的羊水和羊水中的激活素A和抑制素B，以及孕早期的孕妇血清。

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Activin A and inhibin B levels were measured, using a two-site enzyme immunoassay, in extra-embryonic coelomic fluid, amniotic fluid and maternal serum samples retrieved from 23 healthy pregnant women, at 8 (n=8), 9 (n=8), and 10 (n=7) weeks of gestation. Dimeric activin A and inhibin B were measurable in all samples. Median (+/-SEM) activin A concentrations in coelomic fluid (0.98+/-0.34 ng/ml) were significantly higher than in maternal serum (0.68+/-0.05 ng/ml) and in amniotic fluid (0.09+/-0.04 ng/ml) (P<0.05). Maternal serum activin A levels were significantly higher than amniotic fluid concentrations. Median (+/-SEM) inhibin B concentrations in coelomic fluid (24.32+/-6.02 pg/ml) were significantly higher than in maternal serum (5.94+/-0.97 pg/ml) and in amniotic fluid (6.31+/-1.53 pg/ml) (P<0.05), while no significant difference between maternal serum levels and amniotic fluid concentrations was found. No significant difference in activin A and inhibin B levels in extra-coelomic fluid, amniotic fluid, and maternal serum throughout the 3 weeks of pregnancy was found. The present study showed that coelomic fluid is an important reservoir of activin A and inhibin B, supporting the hypothesis that the extra-embryonic coelom may have a secretory role during the first 11 weeks of gestation.
机译：使用两点酶免疫测定法，从8位（n = 8），9位（n = 8）从23位健康孕妇中提取的胚外腔积液，羊水和母体血清样品中测量了激活素A和抑制素B的水平。 ）和10（n = 7）孕周。在所有样品中均可以测量二聚激活素A和抑制素B。结肠液（0.98 +/- 0.34 ng / ml）中的（+/- SEM）激活素A浓度显着高于母体血清（0.68 +/- 0.05 ng / ml）和羊水（0.09 +/- 0.04） ng / ml）（P <0.05）。孕妇血清激活素A水平明显高于羊水浓度。结肠液（24.32 +/- 6.02 pg / ml）中抑制素B的中位数（+/- SEM）显着高于母体血清（5.94 +/- 0.97 pg / ml）和羊水中（6.31 +/- 1.53） pg / ml）（P <0.05），而孕妇血清水平和羊水浓度之间没有显着差异。在整个妊娠的三周中，未发现结肠腔外液，羊水和母体血清中激活素A和抑制素B的水平没有显着差异。目前的研究表明，体液是激活素A和抑制素B的重要储藏体，支持了胚外体腔在妊娠的前11周中可能具有分泌作用的假​​设。

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