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首页> 外文期刊>Chemical Engineering Science >EVALUATION OF BATCH AND SEMI-BATCH REACTOR OPERATION FOR ENZYMATIC REACTIONS WITH INHIBITORY KINETICS
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EVALUATION OF BATCH AND SEMI-BATCH REACTOR OPERATION FOR ENZYMATIC REACTIONS WITH INHIBITORY KINETICS

机译：抑制动力学的酶反应批处理和半间歇反应器操作的评估

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摘要

Two enzymatic reaction sequences in which one of the intermediate products is the desired one were examined under conditions of batch and semi-batch reactor operation. Semi-batch operation involves a non-instantaneous filling phase during which reaction also occurs. The kinetics were assumed to involve substrate inhibition. The effect of various operating parameters -feeding rate, reactant concentration in the feed-stream, and minimum to maximum volume of reactor contents- on the performance of semi-batch operation was examined. It was found that operating parameters can be optimally selected in order to maximize the yield of the desired product. Semi-batch operation under optimal conditions was found to be superior to batch operation on the basis of desired product yield. Implications of the results for waste minimization in pharmaceutical and specialty chemicals production are discussed. [References: 7]
机译：在间歇和半间歇反应器操作的条件下检查了两种酶促反应序列，其中一种中间产物是所需的。半间歇操作涉及一个非瞬时填充阶段，在此阶段还会发生反应。动力学被认为涉及底物抑制。研究了各种操作参数-进料速度，进料流中的反应物浓度以及反应器内容物的最小至最大体积-对半间歇操作性能的影响。已经发现，可以最佳地选择操作参数，以使所需产物的产率最大化。基于理想的产品收率，发现在最佳条件下的半间歇操作优于间歇操作。讨论了将结果减少到最低限度的制药和特种化学品生产中的意义。 [参考：7]

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