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首页> 外文期刊>Biomaterials >Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer.
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Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer.

机译：亚铁磁性磁铁矿微球的制备，用于癌症的原位高温治疗。

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Ferrimagnetic microspheres 20-30mum in diameter are useful as thermoseeds for inducing hyperthermia in cancers, especially for tumors located deep inside the body. The microspheres are entrapped in the capillary bed of the tumors when they are implanted through blood vessels and heat cancers locally by their hysteresis loss when placed under an alternating magnetic field. In the present study, preparation of magnetite (Fe(3)O(4)) microspheres 20-30mum in diameter was attempted by melting powders in high-frequency induction thermal plasma, and by precipitation from aqueous solution. The microspheres prepared by melting powders in high-frequency induction thermal plasma were composed of a large amount of Fe(3)O(4) and a small amount of wustite (FeO), and those subsequently heat treated at 600 degrees C for 1h under 5.1x10(3)Pa were fully composed of Fe(3)O(4) 1mum in size. The saturation magnetization and coercive force of the heat-treated microspheres were 92emug(-1) and 50Oe, respectively. The heat generation of the heat-treated microspheres was estimated to be 10Wg(-1), under 300Oe and 100kHz. The microspheres prepared by precipitation from aqueous solution consisted of beta-FeOOH, and those subsequently heat treated at 400 degrees C for 1h in a 70% CO(2)+30% H(2) atmosphere consisted of Fe(3)O(4) crystals 50nm in size. The saturation magnetization and coercive force of the heat-treated microspheres were 53emug(-1) and 156Oe, respectively. The heat generation of the heat-treated microspheres was estimated to be 41Wg(-1), under 300Oe and 100kHz. The latter microspheres are believed to be promising thermoseeds for hyperthermic treatment of cancer.
机译：直径为20-30μm的亚铁磁性微球可用作热种子，可在癌症中诱导高温，特别是对于体内深处的肿瘤。当微球通过血管植入时，它们被包裹在肿瘤的毛细血管中;当置于交变磁场下时，微球因其磁滞损耗而局部加热癌症。在本研究中，尝试通过在高频感应热等离子体中熔化粉末并从水溶液中沉淀来制备直径20-30μm的磁铁矿（Fe（3）O（4））微球。通过在高频感应热等离子体中熔化粉末而制备的微球由大量的Fe（3）O（4）和少量的辉石（FeO）组成，随后在600摄氏度的温度下热处理1小时。 5.1x10（3）Pa完全由尺寸为1m的Fe（3）O（4）组成。热处理后的微球的饱和磁化强度和矫顽力分别为92emug（-1）和50Oe。在300Oe和100kHz下，经热处理的微球的发热估计为10Wg（-1）。通过从水溶液中沉淀制备的微球由β-FeOOH组成，随后在400％的温度下于70％CO（2）+ 30％H（2）气氛中热处理1h的微球由Fe（3）O（4 ）大小为50nm的晶体。热处理后的微球的饱和磁化强度和矫顽力分别为53emug（-1）和156Oe。在300Oe和100kHz下，经热处理的微球的发热估计为41Wg（-1）。据信后一种微球是用于癌症高温治疗的有前途的热种子。

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