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首页> 外文期刊>Chemical Senses >Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs
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Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs

机译：从黄热蚊（埃及伊蚊）中识别化学感受器，该化学感受器在嗅觉和味觉器官中高度保守并表达

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摘要

Aedes aegypti is a highly anthropophilic mosquito responsible for the transmission of dengue and yellow fever around the world. Like other mosquitoes, the biting and host preference behaviors of this disease vector are largely influenced by its sense of smell, which is presumably facilitated by G protein-coupled receptor signaling cascades. Here, we report the identification and characterization of AaOr7, the first candidate odorant receptor from Ae. aegypti. This receptor displays extremely high primary amino acid conservation with AgOr7 another candidate odorant receptor identified in the Aftrotropical malaria vector, Anopheles gambiae as well as several previously identified candidate odorant receptors in Drosophila melanogaster and other insects. Its transcript is expressed in adult chemosensory tissues and during several stages of Ae. aegypti development. Within the adult olfactory system, AaOr7 protein is found specifically within most antennal and maxillary palp sensilla, as well as in a subset of proboscis sensilla. These results are consistent with a role for AaOr7 in olfaction and gustation supporting the hypothesis that AaOr7 and its orthologs may be of general importance to chemosensory processes throughout the lifetime of an insect.
机译：埃及伊蚊是一种高度嗜人类的蚊子，负责在全球传播登革热和黄热病。像其他蚊子一样，该疾病载体的咬人和宿主偏爱行为在很大程度上受到其嗅觉的影响，这可能是由G蛋白偶联受体信号传导级联促进的。在这里，我们报告的鉴定和表征AaOr7，从Ae的第一个候选的气味受体。埃及。该受体显示出极高的一级氨基酸保守性，而AgOr7是在嗜热性疟疾载体冈比亚按蚊中发现的另一种候选气味受体，以及果蝇和其他昆虫中几种先前鉴定的候选气味受体。它的转录物在成年的化学感觉组织中和Ae的几个阶段表达。埃及发展。在成人的嗅觉系统中，AaOr7蛋白特别在大多数触角和上颌触诊中以及在长鼻中被发现。这些结果与AaOr7在嗅觉和味觉中的作用相吻合，支持了以下假设：AaOr7及其直系同源物可能在昆虫的整个生命周期中对化学感觉过程具有普遍重要性。

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