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首页> 外文期刊>Chemical Senses >Sex-specific responses to urinary chemicals by the mouse vomeronasal organ
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Sex-specific responses to urinary chemicals by the mouse vomeronasal organ

机译：小鼠犁鼻器器官对尿化学物质的性别特异性反应

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摘要

Social behaviors of most mammals are affected by chemical signals, pheromones, exchanged between conspecifics. Previous experiments have shown that behavioral responses to the same pheromone differ depending on the sex and endocrine status of the respondent. Although the exact mechanism of this dimorphism is not known, one possible contributor may be due to sexually dimorphic receptors or due to differences in central processing within the brain. In order to investigate the differences in response between male and female mice to the same pheromonal stimulus two urinary compounds (2-heptanone and 2,5-dimethylpyrazine) were used to stimulate the production of Inositol (1,4,5)-trisphosphate (IP3) in microvillar membrane preparations of the vomeronasal organ as an indirect measurement of pheromonal stimulation. Incubation of such membranes from prepubertal mice with urine from the same sex or opposite sex, results in an increase in production of IP3. This stimulation is mimicked by GTPgammaS and blocked by GDPbetaS. Furthermore we found that 2-heptanone present in both male and female urine was capable of stimulating increased production of IP3 in the female VNO but not the male VNO. Finally, 2,5-dimethylpyrazine present only in female urine was also only capable of stimulating increased production of IP3 in the female VNO.
机译：大多数哺乳动物的社会行为都受到种间交换的化学信号，信息素的影响。先前的实验表明，对相同信息素的行为反应取决于被访者的性别和内分泌状态。尽管尚不清楚这种二态性的确切机制，但一个可能的原因可能是由于性二态性受体或由于大脑内部中央处理的差异。为了研究雄性和雌性小鼠对相同的信息素刺激的反应差异，使用了两种泌尿化合物（2-庚酮和2,5-二甲基吡嗪）刺激肌醇（1,4,5）-三磷酸（ IP3）在犁鼻器器官的微绒膜制剂中作为间接测量的信息素刺激。将这种膜与来自同性或异性的尿液一起从青春期前小鼠中孵育，会导致IP3的产生增加。 GTPgammaS模仿了这种刺激，GDPbetaS阻止了这种刺激。此外，我们发现，男性和女性尿液中均存在2-庚酮能够刺激女性VNO而非男性VNO中IP3产生的增加。最后，仅存在于女性尿液中的2，5-二甲基吡嗪也仅能够刺激女性VNO中IP3的产生增加。

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