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首页> 外文期刊>Chemical Senses >The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine
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The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine

机译：在对蔗糖八乙酸酯和奎宁差异敏感的小鼠品系中，味蕾种群对避免苦味的贡献

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摘要

Mice of the SWR/J (SW) strain avoid orally delivered sucrose octa-acetate (SOA), whereas the mice of the C3HeB/FeJ (C3) strain are insensitive to SOA. Mice of both strains and of a congenic strain (C3.SW) that shares more than 99% of the C3 genome, were tested in a taste-salient brief-access taste test for responses to SOA and quinine hydrochloride, before and after transection of the glossopharyngeal or chorda tympani nerve, or sham surgery. Prior to surgery, congenic SOA tasters (C3.SWT) were phenotypically identical to the SW strain in avoidance of SOA, but showed a greater reduction in sensitivity after nerve transection. For quinine avoidance, which is thought to be a polygenic trait, SW mice showed the greatest sensitivity to quinine, C3 the least and C3.SWT mice were different from both parental strains, showing intermediate sensitivity. Nerve transections had only a moderate effect on quinine sensitivity, suggesting that both anterior and posterior taste bud fields contribute to behavioral quinine avoidance. These findings are discussed with regard to the distribution in the oral cavity of putative taste receptors for quinine and SOA and the peripheral organization of bitter taste.
机译：SWR / J（SW）品系的小鼠避免口服蔗糖八乙酸酯（SOA），而C3HeB / FeJ（C3）品系的小鼠对SOA不敏感。这两种菌株和共享超过C3基因组99％的同系菌株（C3.SW）的小鼠都在进行味觉短暂访问味觉测试时测试了其横切前后对SOA和盐酸奎宁的反应。舌咽或鼓膜鼓膜神经或假手术。手术前，同基因SOA品尝者（C3.SWT）在表型上与SW菌株相同，以避免SOA，但在神经横断后敏感性显着降低。为了避免被认为是多基因性的奎宁，SW小鼠对奎宁的敏感性最高，C3最低，C3.SWT小鼠与两个亲本菌株均不同，显示出中等的敏感性。神经横切对奎宁敏感性只有中等程度的影响，表明前味蕾区和后味蕾区都有助于避免行为性奎宁。讨论了有关奎宁和SOA的假定味觉受体在口腔中的分布以及苦味的外围组织的这些发现。

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