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首页> 外文期刊>Chemical Senses >The Role of the Human Hippocampus in Odor-Place Associative Memory
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The Role of the Human Hippocampus in Odor-Place Associative Memory

机译：人海马在气味关联记忆中的作用

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摘要

Hippocampal lesions in rodents impair both object-place and odor-place associative memory. Subjects with hippocampal damage have impaired associative memory such as object-place memory. Whereas studies have investigated some types of associative memory, no investigation has specifically examined odor-place associative memory in subjects with well-defined amnesia. It is unknown whether amnesic subjects with hippocampal damage would be impaired on an odor-place associative task. We investigated the effect of hippocampal damage in amnesic subjects with hippocampal atrophy on odor-place associative memory and recognition memory tasks. Amnesic and healthy comparison subjects matched for age and education were tested on an odor-place associative task, an odor recognition task, and a place recognition task. The odor-place associative task required subjects to associate 6 odors with 6 spatial locations on a board. The recognition tasks required subjects to identify the 6 odors and the 6 locations that were presented during the associative task. Amnesic subjects were impaired for odor-place memory and place recognition, but not odor recognition compared with comparison subjects. These results suggest that the human hippocampus is necessary for odor-place associative memory and spatial recognition memory. These data provide support for the idea that odor-place associative memory is mediated by the hippocampus in both humans and rodents, suggesting an evolutionary continuity in cognitive function assigned to the hippocampus.
机译：啮齿动物中的海马损伤会损害对象位置和气味位置的联想记忆。有海马损伤的对象的联想记忆力受损，例如对象位置记忆力受损。尽管研究已经研究了某些类型的联想记忆，但没有研究专门研究了患有明确失忆症患者的气味-地方联想记忆。尚不清楚在异味场所关联任务中是否会损害具有海马损伤的健忘受试者。我们调查了在海马萎缩症的失忆对象中海马损伤对气味-地方联想记忆和识别记忆任务的影响。对年龄和文化程度相匹配的健忘症和健康对照受试者进行了气味场所关联任务，气味识别任务和场所识别任务的测试。气味-地方关联任务要求受试者将6种气味与板上的6个空间位置关联。识别任务要求受试者识别在关联任务中出现的6种气味和6个位置。与比较对象相比，健忘症患者的气味记忆和位置识别能力受损，但气味识别能力并未受损。这些结果表明，人类海马是气味-地方联想记忆和空间识别记忆所必需的。这些数据支持了在人和啮齿动物中海马介导的气味-地方联想记忆的想法，表明了分配给海马的认知功能的进化连续性。

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