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首页> 外文期刊>Chemical Senses >Oral Thresholds and Suprathreshold Intensity Ratings for Free Fatty Acids on 3 Tongue Sites in Humans: Implications for Transduction Mechanisms
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Oral Thresholds and Suprathreshold Intensity Ratings for Free Fatty Acids on 3 Tongue Sites in Humans: Implications for Transduction Mechanisms

机译：人体三个舌头部位的游离脂肪酸的口服阈值和阈上强度等级：对转导机制的启示

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Multiple putative free fatty acid (FFA) transduction mechanisms have been identified in the oral cavity. They reportedly differ in their distribution on the tongue and each has a unique range of ligand specificities. This suggests that there should be regional differences in sensory responses to varying FFAs. This was assessed through spatial testing with caproic (C), lauric (L), and stearic (S) FFAs among 35 healthy adults. Stimuli were applied to the fungiform (FU), foliate (FO), and circumvallate (CV) papillae with a cotton-tipped applicator. Oral detection thresholds were measured by an ascending, 3-alternative, forced-choice, sip and spit procedure. Intensity ratings were obtained on the general labeled magnitude scale. Nongustatory cues were minimized by testing with the nares blocked, eyes covered, and by masking tactile cues with the addition of gum acacia and mineral oil to the stimuli vehicle. Thresholds were obtained from nearly all individuals at each site, and the concentration was similar across the 3 FFAs. Absolute intensity ratings differed significantly with C > L > S overall and at the CV and FO papillae. At the FU papillae, the L and S ratings were comparable. Ratings were highest at the FU followed by the CV and then the FO papillae. Slopes of the concentration-intensity rating functions were higher for L compared with C and S at the CV papillae as well as both L and C compared with S at the FO papillae. However, overall, slopes were comparable across sites. These findings strengthen evidence for oral FFA perception in humans by replicating threshold sensitivity findings and documenting monotonic scaling ability for these stimuli. Further, they challenge current views on transduction as sensory responsiveness was observed at tongue sites not predicted to support FFA detection.
机译：在口腔中已鉴定出多种推定的游离脂肪酸（FFA）转导机制。据报道，它们在舌头上的分布不同，并且每个都有独特的配体特异性范围。这表明对不同FFA的感觉反应应该存在区域差异。这是通过在35名健康成年人中用己酸（C），月桂酸（L）和硬脂酸（S）FFA进行空间测试来评估的。用棉签将刺激物施加到真菌状（FU），叶酸盐（FO）和环戊酸盐（CV）乳头上。口服检测阈值通过递增，3替代，强制选择，饮和吐痰程序进行测量。强度等级是在一般标记的量表上获得的。通过测试鼻孔阻塞，遮盖眼睛以及通过在刺激媒介物中添加阿拉伯胶和矿物油来掩盖触觉提示，从而将非味觉提示降至最低。从每个站点的几乎所有个人获得阈值，并且在三个FFA中的浓度相似。总体的C> L> S以及CV和FO乳头处的绝对强度等级显着不同。在FU乳突上，L和S等级相当。 FU评分最高，其次是CV，然后是FO乳头。与C和S相比，L在CV乳头处的浓度-强度等级函数的斜率更高，L和C与FO乳头上的S的斜率都比S高。但是，总体而言，各个站点的坡度相当。这些发现通过复制阈值敏感性发现并记录这些刺激的单调缩放能力，为人类口服FFA感知提供了证据。此外，他们挑战了当前有关转导的观点，因为在未预计支持FFA检测的舌头部位观察到了感觉反应。

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