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首页> 外文期刊>Chemical Senses >Timing of Neuronal Intermediate Filament Proteins Expression in the Mouse Vomeronasal Organ During Pre- and Postnatal Development An Immunohistochemical Study
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Timing of Neuronal Intermediate Filament Proteins Expression in the Mouse Vomeronasal Organ During Pre- and Postnatal Development An Immunohistochemical Study

机译：产前和产后发育过程中小鼠犁鼻鼻器官中神经元中间丝蛋白表达的时机免疫组织化学研究

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Several types of intermediate filament proteins are expressed in developing and mature neurons;they cooperate with other cytoskeletal components to sustain neuronal function from early neurogenesis onward.In this work the timing of expression of nestin,peripherin,internexin,and the neuronal intermediate filament triplet [polypeptide subunits of low (NF-L),medium (NF-M),and high (NF-H) molecular weight] was investigated in the developing fetal and postnatal mouse vomeronasal organ (VNO) by means of immunohistochemistry.The results show that the sequence of expression of intermediate filament proteins is internexin,nestin,and NF-M in the developing vomeronasal sensory epithelium;internexin,peripherin,and NF-M in the developing vomeronasal nerve;and nestin,internexin and peripherin,NF-L,and NF-M in the nerve supply to accessory structures of the VNO.At sexual maturity (2 months) NF-M is only expressed in vomeronasal neurons and NF-M,NF-L and peripherin are expressed in extrinsic nerves supplying VNO structures.The differential distribution of intermediate filament proteins in the vomeronasal sensory epithelium and nerve is discussed in terms of the cell types present therein.It is concluded that several intermediate filament proteins are sequentially expressed during intrauterine development of the VNO neural structures in a different pattern according to the different components of the VNO.
机译：几种类型的中间丝蛋白在发育中和成熟的神经元中表达;它们与其他细胞骨架成分协同作用，从早期神经发生开始就维持神经元功能。在这项工作中，巢蛋白，外周蛋白，内毒素和神经元中间丝三联体的表达时间[通过免疫组织化学方法研究了发育中的胎儿和出生后小鼠犁鼻器器官（VNO）的低（NF-L），中（NF-M）和高（NF-H）多肽亚基。结果表明：中间丝蛋白的表达顺序是在发育中的犁鼻器感觉上皮中有internexin，nestin和NF-M;在发育中的犁鼻神经中有internexin，peripherin和NF-M;还有nestin，internexin和peripherin，NF-L和在性交成熟（2个月）时，NF-M仅在犁鼻神经元中表达，而NF-M，NF-L和周围蛋白在外在神经中表达。根据其中存在的细胞类型讨论了中间丝蛋白在犁鼻感觉上皮和神经中的差异分布。结论是在子宫内VNO神经结构的子宫内发育过程中顺序表达了几种中间丝蛋白。根据VNO的不同组成部分的不同模式。

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