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Olfactory Cilia: Linking Sensory Cilia Function and Human Disease

机译:嗅纤毛:连接感觉纤毛功能和人类疾病。

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摘要

The olfactory system gives us an awareness of our immediate environment by allowing us to detect airborne stimuli The components necessary for detection of these odorants are compartmentalized in the cilia of olfactory sensory neurons Cilia are microtubule-based organelles, which can be found projecting from the surface of almost any mammalian cell and are critical for proper olfactory function. Mislocalization of ciliary proteins and/or the loss of cilia cause impaired olfactory function which is now recognized as a clinical manifestation of a broad class of human diseases, termed ciliopathies. Future work investiqatinq the mechanisms of olfactory cilia function will provide us important new information regarding the pathogenesis of human sensory perception diseases.
机译:嗅觉系统使我们能够检测到空气中的刺激,从而使我们了解了周围的环境。嗅觉神经元的纤毛中分隔了检测这些气味所必需的成分。纤毛是微管型细胞器,可以从表面突出。几乎所有哺乳动物细胞的细胞,对于适当的嗅觉功能至关重要。睫状蛋白的错误定位和/或纤毛的丧失引起嗅觉功能受损,这现已被认为是人类广泛疾病的临床表现,称为纤毛病。未来研究嗅觉纤毛功能的机制将为我们提供有关人类感觉知觉疾病发病机理的重要新信息。

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