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首页> 外文期刊>Chemical Senses >Presence of Neuropathic Pain May Explain Poor Performances on Olfactory Testing in Diabetes Mellitus Patients
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Presence of Neuropathic Pain May Explain Poor Performances on Olfactory Testing in Diabetes Mellitus Patients

机译：神经性疼痛的存在可能说明糖尿病患者的嗅觉测试表现不佳

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Olfactory dysfunction in neurodegenerative conditions such as Parkinson's syndrome and Alzheimer's disease can hallmark disease onset. We hypothesized that patients with diabetes mellitus, a condition featuring peripheral and central neurodegen-eration, would have decreased olfaction abilities. We examined participants with diabetic peripheral neuropathy, participants with diabetes without diabetic peripheral neuropathy, and control participants in blinded fashion using standardized Sniffin' Sticks. Diabetic peripheral neuropathy severity was quantified using the Utah Early Neuropathy Scale. Further subcategoriza-tion of diabetic peripheral neuropathy based on presence of neuropathic pain was performed with Douleur Neuropathique 4 Questionnaires. Participants with diabetes had decreased olfactory sensitivity, impaired olfactory discrimination abilities, and reduced odor identification skills when compared with controls. However, loss of olfaction ability was, at least partially, attributed to presence of neuropathic pain on subcategory assessment, although pain severity was not associated with dysfunction. Those participants with diabetes without diabetic peripheral neuropathy and those with diabetic peripheral neuropathy without neuropathic pain had similar olfactory function as controls in general. The presence of neuropathic pain, associated with limited attention and concentration, may explain at least a portion of the olfactory dysfunction witnessed in the diabetic patient population.
机译：在神经退行性疾病如帕金森氏综合症和阿尔茨海默氏病中，嗅觉功能障碍可成为疾病发作的标志。我们假设糖尿病患者（一种以周围和中枢神经变性为特征的疾病）的嗅觉能力会下降。我们检查了患有糖尿病性周围神经病变的参与者，没有糖尿病性周围神经病变的糖尿病参与者，并使用标准化的Sniffin's Sticks以盲法控制了参与者。糖尿病周围神经病变的严重程度使用犹他州早期神经病变量表进行量化。使用Douleur Neuropathique 4问卷对基于神经性疼痛的糖尿病周围神经病变进行了进一步的分类。与对照组相比，糖尿病患者的嗅觉敏感性降低，嗅觉辨别能力受损，气味识别能力下降。然而，嗅觉能力的丧失至少部分归因于亚类评估中神经性疼痛的存在，尽管疼痛的严重程度与功能障碍无关。那些没有糖尿病性周围神经病变的糖尿病患者和那些没有神经性疼痛的糖尿病周围神经病的患者，其嗅觉功能通常与对照组相似。与有限的注意力和集中力相关的神经性疼痛的存在可以解释在糖尿病患者人群中见证的至少一部分嗅觉功能障碍。

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