Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate

Guney E.; Yilmaz V.T.; Ari F.; Buyukgungor O.; Ulukaya E.

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Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate

机译：含双（2-吡啶基甲基）胺和糖精的钯（II）和铂（II）配合物的合成，表征，结构和细胞毒性

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New palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine (bpma) and saccharinate (sac), [Pd(bpma)(sac)](sac) ·2H2O (1), [Pt(bpma)(sac)](sac)·2H_2O (2), [Pd(bpma)Cl](sac)·2H_2O (3) and [Pt(bpma)(sac)]Cl·1. 5H_2O (4), were synthesized and characterized by elemental analysis, IR, NMR and TG-DTA. A single-crystal X-ray analysis of 3 and 4 proved a distorted square-planar geometry around the metal ions with one tridentate bpma ligand and one Cl or sac monoanion. The [Pd(bpma)Cl]~+ ions in 3 form dimers by intermolecular N-H?Cl and Pd?Pd interactions. The cations reside in the centers of a hydrogen-bonded honeycomb network formed by the uncoordinated sac ions and the lattice water molecules, while the cations of 4 are connected by N-H?Cl and OW-H?O hydrogen bonds into one-dimensional chains. Cyclic planar tetrameric and trimeric water clusters were observed in 3 and 4, respectively. Cytotoxicity of 1-4 was tested against A549, C6 and CHO cells. Although 2 and 4 have no cytotoxicity, the best results were achieved for 1 and 3. In particular, the cyctotoxic activity of 3 is comparable to cisplatin.

机译：含有双（2-吡啶甲基）胺（bpma）和糖精（sac），[Pd（bpma）（sac）]（sac）·2H2O（1），[Pt（bpma）的新型钯（II）和铂（II）配合物）（sac）]（sac）·2H_2O（2），[Pd（bpma）Cl]（sac）·2H_2O（3）和[Pt（bpma）（sac）] Cl·1。合成了5H_2O（4），并通过元素分析，IR，NMR和TG-DTA对其进行了表征。对3和4进行的单晶X射线分析证明，金属离子周围带有一个三齿bpma配体和一个Cl或囊状单阴离子，其方平面几何形状失真。通过分子间N-H2Cl和Pd？Pd相互作用，使[Pd（bpma）Cl]〜+离子形成3个二聚体。阳离子位于由未配位的囊状离子和晶格水分子形成的氢键蜂窝网络的中心，而4阳离子则通过N-H2Cl和OW-H2O氢键连接成一维链。在3和4中分别观察到环状平面四聚体和三聚体水簇。测试了针对A549，C6和CHO细胞的1-4的细胞毒性。尽管2和4没有细胞毒性，但1和3却获得了最佳结果。特别是3的细胞毒性活性与顺铂相当。

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2011年第1期|共9页
作者
Guney E.; Yilmaz V.T.; Ari F.; Buyukgungor O.; Ulukaya E.;
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正文语种 eng
中图分类无机化学;
关键词
Bis(2-pyridylmethyl)amine; Cytotoxic activity; Palladium(II); Platinum(II); Saccharinate; Water cluster;

机译：双（2-吡啶基甲基）胺;细胞毒活性;钯（II）;铂（II）;糖精;水簇;

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Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate

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