Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

Kuheli Das; Amitabha Datta; Pei-Hsin Liu; Jui-Hsien Huang; Chin-Lin Hsu; Wei-Tang Chang; Barbara Machura; Chittaranjan Sinha

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Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

机译：N，O供体席夫碱钴（II）配合物的结构表征及其对癌细胞的活性

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2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N_2O_2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N_2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)_2(NCS)]NO_3 (1) and [Co(LH)_2(N_3)]NO_3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV–Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC_(50) in human colorectal carcinoma cells (COLO 205 cells).

机译：2-[{[2-（二甲基氨基）乙基]亚氨基}甲基] -6-甲氧基苯酚（LH）是潜在的四齿单阴离子N_2O_2螯合剂;然而，该前体以两种方式与钴（II）中心配位，即中性二齿-NO和齿状-N_2O，以及假卤化物（如硫氰酸盐和叠氮化物），以提供[Co（LH）_2（NCS）] NO_3（ 1）和[Co（LH）_2（N_3）] NO_3（2）。两种配合物均通过光谱分析（IR，UV-Vis），热和氧化还原研究表征。 1和2的室温磁矩分别为4.91和4.93 B.M.单晶X射线衍射分析证实了Co（II）周围扭曲的八面体几何形状。这两个复合物（1和2）抑制人肺癌细胞（A549细胞），人结肠直肠癌细胞（COLO 205细胞），人肝细胞癌细胞（PLC5细胞）和人成纤维细胞（NIH3T3）的细胞生长。复合物2在人结肠直肠癌细胞（COLO 205细胞）中显示出更高的抑制活性，IC_（50）为46.00±1.09μM。

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2014年第null期|共6页
作者
Kuheli Das; Amitabha Datta; Pei-Hsin Liu; Jui-Hsien Huang; Chin-Lin Hsu; Wei-Tang Chang; Barbara Machura; Chittaranjan Sinha;
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正文语种 eng
中图分类无机化学;
关键词
Cobalt(II)–Schiff base complex; Crystal structure; Spectral properties; Bio-study;

机译：钴（II）-席夫碱配合物;晶体结构;光谱性质;生物研究;

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1. Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells [J] . Kuheli Das, Amitabha Datta, Pei-Hsin Liu, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2014,第Null期

机译：N，O供体席夫碱钴（II）配合物的结构表征及其对癌细胞的活性
2. Nickel(II), copper(II), and cobalt(II) complexes derived from a new unsymmetrical ONS donor Schiff base ligand: synthesis, characterization, crystal structure, and catalytic activities [J] . MUKUL KALITA, PRASANTA GOGOI, PRANJIT BARMAN Journal of Coordination Chemistry . 2014,第13a14期

机译：从新的不对称ONS供体Schiff碱配体衍生的镍（II），铜（II）和钴（II）配合物：合成，表征，晶体结构和催化活性
3. Synthesis, characterization, and X-ray crystal structure of cobalt(III) complexes with a N_2O_2-donor Schiff base and ancillary ligands. Spectral, antibacterial activity, and electrochemical studies [J] . Mehdi Salehi, Mehdi Amirnasr, Soraia Meghdadi, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2014,第Null期

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4. SPIN CROSSOVER PROPERTIES OF IRON(II) COMPLEXES WITH A N_4O_2 DONOR SET BY EXTENDED Ⅱ-CONJUGATED SCHIFF-BASE LIGANDS [C] . TAKAYOSHI KURODA Symposium on Quantum Information and Quantum Computing . 2013

机译：铁（II）复合物的旋转交叉性能与延伸Ⅱ缀合的席夫碱配体设定的N_4O_2供体
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机译：第一部分：席夫碱配体衍生的某些过渡金属配合物的合成和结构表征第二部分：药理活性化合物的晶体学研究。
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机译：Cu（II），Cu（II），Mn（II），Ni（II），Ni（II）和Cr（III）金属配合物与肝细胞癌（HCAM）癌细胞（HCAM）癌细胞（HCAM）的合成，表征和Cr（II），Ni（II），Ni（II）和Cr（III）金属络合物的合成，表征和细胞毒性研究

Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

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