2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes: Potential antineoplastic activity

Graminha AE; Vilhena FS; Batista AA; Louro SRW; Ziolli RL; Teixeira LR; Beraldo H

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2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes: Potential antineoplastic activity

机译：2-吡啶甲酰胺衍生的硫代半氨基甲酮及其铁（III）配合物：潜在的抗肿瘤活性

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The iron(III) complexes [Fe(2Am4DH)(2)]Cl (1), [Fe(2Am4Me)(2)]Cl (2) and [Fe(2Am4Et)(2)]Cl (3) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives were obtained and characterized by means microanalyses, infrared and EPR spectra. The electrochemical behavior of the complexes was investigated. The thiosemicarbazones and complexes (1) and (2) presented toxicity against Artemia salina at low concentrations. Since this bioassay has a good correlation with cytotoxic activity in human solid tumors, the studied compounds present potential pharmacological applications. (c) 2007 Elsevier Ltd. All rights reserved.

机译：铁（III）配合物[Fe（2Am4DH）（2）] Cl（1），[Fe（2Am4Me）（2）] Cl（2）和[Fe（2Am4Et）（2）] Cl（3）与2-获得了吡啶甲酰胺硫代半碳酮（H2Am4DH）及其N（4）-甲基（H2Am4Me）和N（4）-乙基（H2Am4Et）衍生物，并通过微分析，红外和EPR光谱进行了表征。研究了配合物的电化学行为。硫半脲和配合物（1）和（2）在低浓度下对卤虫卤有毒性。由于该生物测定与人实体瘤中的细胞毒性活性具有良好的相关性，因此所研究的化合物具有潜在的药理应用。（c）2007 Elsevier Ltd.保留所有权利。

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2008年第2期|共5页
作者
Graminha AE; Vilhena FS; Batista AA; Louro SRW; Ziolli RL; Teixeira LR; Beraldo H;
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正文语种 eng
中图分类化学;
关键词
2-pyridineformamide thiosemicarbazones; iron complexes; cytoxicity; Artemia salina; METAL-COMPLEXES; RIBONUCLEOTIDE REDUCTASE; 2-PYRIDINEFORMAMIDE N(4)-METHYLTHIOSEMICARBAZONE; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; 2-FORMYLPYRIDINE THIOSEMICARBAZONE; SPECTRAL CHARACTERIZATION; ANTITUMOR-ACTIVITY; BRINE SHRIMP; AGENTS; ANTIFUNGAL;

机译：2-吡啶甲酰胺硫代半氨基甲磺酸;铁配合物;细胞毒性;卤虫盐;金属配合物;核糖核苷酸还原酶;2-吡啶甲酰胺N（4）-甲基噻吩并咪唑啉;2-苯并吡啶吡啶并噻吩并甲磺酰胺;2-甲酰胺基对苯二甲酰胺;虾;代理商;抗真菌药;

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1. 2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes: Potential antineoplastic activity [J] . Graminha AE, Vilhena FS, Batista AA, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2008,第2期

机译：2-吡啶甲酰胺衍生的硫代半氨基甲酮及其铁（III）配合物：潜在的抗肿瘤活性
2. Cytotoxic activity of iron(III), cobalt(III), nickel(II), zinc(II), and cadmium(II) complexes of 2-acetylpyrazine thiosemicarbazone: crystal structure of the cobalt(III) complex [J] . DONG ZHANG, QIAN LI, MING-XUE LI Journal of Coordination Chemistry . 2010,第6期

机译：2-乙酰基吡嗪硫半碳zone的铁（III），钴（III），镍（II），锌（II）和镉（II）配合物的细胞毒活性：钴（III）配合物的晶体结构
3. Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies [J] . Kaya Busra, Yilmaz Zehra Kubra, Sahin Onur, Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2019,第3期

机译：铁（III） - 和锰（III） - 硫代脲羟基苯并的结构分析和生物学功能：体外抗增殖活性对人体癌细胞，DNA结合和切割研究
4. FUNGICIDAL ACTIVITIES OF PYRIDYL THIOSEMICARBAZONES AND THEIR METAL COMPLEXES [C] . A. Wengel, N. Jacobsen, H. Kolind-Andersen International Congress of Pesticide Chemistry . 1986

机译：吡啶基硫代吡吡吡嗪及其金属配合物的杀真菌活性
5. The structure and reactivity of a series of high-valent oxo complexes of Ru and Mn: Ru(III)-mediated catalytic oxygenation of triphenylphosphine, characterization of binuclear Mn(III,III) and Mn(III,IV) dimers, and mononuclear iron(III) and iron(IV). [D] . Fackler, Nathanael L. P. 1997

机译：Ru和Mn的一系列高价羰基配合物的结构和反应性：Ru（III）介导的三苯膦催化氧化，双核Mn（III，III）和Mn（III，IV）二聚体的表征以及单核铁（III）和铁（IV）。
6. Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones [O] . Iris H. Hall, Merrill C. Miller III, Douglas X. West 1997

机译：硫代咪唑酮镍（II）配合物的抗肿瘤和细胞毒活性
7. Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones [O] . Hall, Iris H., Miller, Merrill C., West, Douglas X. 1997

机译：硫代咪唑酮镍（II）配合物的抗肿瘤和细胞毒活性

2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes: Potential antineoplastic activity

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