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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Synthesis, characterization and biological evaluation of a novel Cu(II) complex with the mixed ligands 2,6-pyridinedicarboxylic acid and 2-aminopyridine
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Synthesis, characterization and biological evaluation of a novel Cu(II) complex with the mixed ligands 2,6-pyridinedicarboxylic acid and 2-aminopyridine

机译：具有混合配体2,6-吡啶二羧酸和2-氨基吡啶的新型Cu（II）配合物的合成，表征和生物学评价

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摘要

A novel bridged binuclear Cu(II) complex with mixed ligands, di-mu-(2-aminopyridine(N,N'))-bis[(2,6-pyridinedicarboxylate)aquacopper( II)] tetrahydrate, formulated as [Cu(mu-ap)(dipic)(H2O)](2)center dot 4H(2)O (1) (dipic = 2,6-pyridinedicarboxylate, ap = 2-aminopyridine), has been synthesized and characterized by elemental, spectral (IR and UV-Vis.), thermal analysis, magnetic measurements and single crystal X-ray diffraction analysis. The central Cu(II) ion resides on a centre of symmetry in a distorted square-pyramid coordination environment comprising of two N atoms, one from dipic and one from the ap ring, two carboxylate O atoms from dipic, and one O atom from water. Intermolecular N-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds and pi-pi stacking interactions seem to be effective in the stabilization of the crystal structure. The free ligands and the complex were also evaluated for their antimicrobial and radical scavenging activities (DPPH = 1,1-diphenyl-2-picrylhydrazyl hydrate) using in vitro microdilution methods. Antimicrobial screening of the free ligands and their complex showed that the free ligands and the complex possess antifungal activity against Candida sp.
机译：新型桥联双核铜（II）配合物，具有混合配体二-（2-氨基吡啶（N，N'））-双[（2,6-吡啶二羧酸盐）quacopper（II）]四水合物，配制成[Cu（ mu-ap）（dipic）（H2O）]（2）中心点4H（2）O（1）（dipic = 2,6-吡啶二羧酸盐，ap = 2-氨基吡啶），并已通过元素光谱表征（红外和紫外可见），热分析，磁测量和单晶X射线衍射分析。中心的Cu（II）离子位于扭曲的方锥配位环境中的对称中心上，该环境包含两个N原子，一个来自二元体，一个来自ap环，两个羧基O原子来自二元体，一个O原子来自水。分子间的N-H中心点中心点中心点O和O-H中心点中心点中心点中心点O的氢键和π-π堆积相互作用似乎对稳定晶体结构有效。还使用体外微稀释方法评估了游离配体和络合物的抗微生物和自由基清除活性（DPPH = 1,1-二苯基-2-吡啶并肼基水合物）。对游离配体及其复合物的抗微生物筛选显示，游离配体和复合物对念珠菌具有抗真菌活性。

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