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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Synthesis and structural characterization of a zinc(II) complex of the mycobactericidal drug isoniazid - Toxicity against Artemia salina
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Synthesis and structural characterization of a zinc(II) complex of the mycobactericidal drug isoniazid - Toxicity against Artemia salina

机译：分枝杆菌药异烟肼锌（II）配合物的合成和结构表征-对卤虫的毒性

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摘要

A new zinc(II) complex of the mycobactericidal drug isoniazid (complex 1) was synthesized and characterized by XRD, vibrational spectroscopy (IR, Raman) and thermogravimetric analysis. The complex is constituted by two isoniazid (INH) molecules, six hydration water molecules and two perchlorate counter-ions for each metal center (C_(12)H_(26)N_6Cl _2O_(16)Zn). Zinc(II) adopts a distorted octahedral geometry, where two INH molecules coordinate in a bidentate manner through the hydrazide group (N, O) and the other two isoniazid residues complete the coordination sphere of zinc(II) through their aromatic nitrogen atoms. This coordination pattern gives rise to a 2-D coordination polymer. Complex 1 belongs to the monoclinic system [a = 8.1190(2), b = 17.977(4), c = 9.1051(2) and β = 100.87(3)°], space group P2_1. A biological assay with Artemia salina was also performed. Complex 1 is almost 8.5 times more active than the free ligand. Its toxicity against A. salina correlates well with the cytotoxic activity for some human solid tumors. Therefore, antitumoral properties could be expected from complex 1.
机译：合成了一种新的分枝杆菌药异烟肼的锌（II）配合物（配合物1），并通过XRD，振动光谱（IR，拉曼）和热重分析对其进行了表征。对于每个金属中心，该络合物由两个异烟肼（INH）分子，六个水合水分子和两个高氯酸盐抗衡离子（C_（12）H_（26）N_6Cl _2O_（16）Zn）组成。锌（II）采用扭曲的八面体几何形状，其中两个INH分子通过酰肼基团（N，O）以双齿方式进行配位，而其他两个异烟肼残基则通过其芳香族氮原子完善了锌（II）的配位范围。这种配位模式产生2-D配位聚合物。复合体1属于单斜系统[a = 8.1190（2），b = 17.977（4），c = 9.1051（2）和β= 100.87（3）°]，空间群P2_1。还进行了卤虫卤虫的生物学测定。复合物1的活性几乎是游离配体的8.5倍。它对盐沼曲霉的毒性与某些人类实体瘤的细胞毒性活性密切相关。因此，复合物1有望具有抗肿瘤特性。

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