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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Manganese(II) complexes with N~4-methyl-4-nitrobenzaldehyde, N~4-methyl-4-nitroacetofenone, and N~4-methyl-4- nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi
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Manganese(II) complexes with N~4-methyl-4-nitrobenzaldehyde, N~4-methyl-4-nitroacetofenone, and N~4-methyl-4- nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi

机译：N〜4-甲基-4-硝基苯甲醛，N〜4-甲基-4-硝基乙酰丙酮和N〜4-甲基-4-硝基二苯甲酮硫半脲锰（II）配合物：体外对克氏锥虫的活性研究

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摘要

Thiosemicarbazones are known to be active against different pathogenic microorganisms including Trypanosoma cruzi, the etiological agent of Chagas disease. In the search for new therapeutic drugs against this illness, the complexes [Mn(H4NO_2Fo4M)_2Cl_2] (1), [Mn(H4NO_2Ac4M)_2Cl_2] (2) and [Mn(H4NO _2Bz4M)_2Cl_2] (3) of N~4-methyl-4- nitrobenzaldehyde thiosemicarbazone (H4NO_2Fo4M), N ~4-methyl-4-nitroacetophenone thiosemicarbazone (H4NO_2Ac4M) and N~4-methyl-4-nitrobenzophenone thiosemicarbazone (H4NO _2Bz4M) were obtained and screened in vitro against bloodstream and intracellular forms of T. cruzi. H4NO_2Fo4M, H4NO_2Ac4M and their Mn(II) complexes displayed poor effect on bloodstream trypomastigotes, with IC_(50) values ranging from 68 to >200 μM. However, although H4NO_2Bz4M was also not active, its corresponding Mn(II) complex presented high effect on this T. cruzi form, with an IC_(50) value of 19 μM. The effect of complex (3), against trypomastigotes of T. cruzi supports further in vitro as well as in vivo studies.
机译：已知硫代氨基甲唑酮对不同的病原微生物具有活性，包括南美锥虫病的病原体克鲁氏锥虫。在寻找针对这种疾病的新治疗药物时，N〜4的复合物[Mn（H4NO_2Fo4M）_2Cl_2]（1），[Mn（H4NO_2Ac4M）_2Cl_2]（2）和[Mn（H4NO _2Bz4M）_2Cl_2]（3）获得了-甲基-4-硝基苯甲醛硫半乳糖（H4NO_2Fo4M），N〜4-甲基-4-硝基苯乙酮硫半糖（H4NO_2Ac4M）和N〜4-甲基-4-硝基二苯甲酮硫半糖（H4NO _2Bz4M），并针对血流和细胞内形式进行了体外筛选T. cruzi。 H4NO_2Fo4M，H4NO_2Ac4M及其Mn（II）配合物对血流线虫的表现较差，IC_（50）值范围从68到> 200μM。但是，尽管H4NO_2Bz4M也不起作用，但其相应的Mn（II）配合物对该曲霉菌表现出很高的效果，IC_（50）值为19μM。配合物（3）对抗克氏锥虫的拟鞭毛体的作用进一步支持了体外和体内研究。

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