Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)_3Cl(PhSe(CH_2)_2SePh), Re(CO) _3Cl(PhSe(CH_2)_3SePh

Kermagoret A.; Morgant G.; DAngelo J.; Tomas A.; Roussel P.; Bastian G.; Collery P.; Desma?le D.

首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)_3Cl(PhSe(CH_2)_2SePh), Re(CO) _3Cl(PhSe(CH_2)_3SePh

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Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)_3Cl(PhSe(CH_2)_2SePh), Re(CO) _3Cl(PhSe(CH_2)_3SePh

机译：四种rh（I）双硒醚复合物的几种人肿瘤细胞系的合成，结构表征和生物学活性：Re（CO）_3Cl（PhSe（CH_2）_2SePh），Re（CO）_3Cl（PhSe（CH_2）_3SePh

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Four novel rhenium(I) diseleno-ethers complexes, namely Re(CO) _3Cl(PhSe(CH_2)_2SePh) (5), Re(CO) _3Cl(PhSe(CH_2)_3SePh) (6), Re(CO) _3Cl(HO_2C-CH_2Se(CH2) _2SeCH_2-CO_2H) (7) and Re(CO) _3Cl(HO_2C-CH_2Se(CH2) _3SeCH_2-CO_2H) (8), have been synthesized by reaction of Re(CO)5Cl with the corresponding bidentate ligands. Structures of 5 and 6 were established by single-crystal X-ray diffraction analysis. Complexes 7 and 8 were identified by elemental analysis, 1H NMR-, IR- and mass spectroscopy. The antiproliferative activity of these complexes against four solid human tumor cells was determined. The water-soluble disodium salts of complexes 7 and 8 exhibited marked activities against MCF-7 breast cancer cells.

机译：四种新颖的rh（I）二硒醚复合物，分别是Re（CO）_3Cl（PhSe（CH_2）_2SePh）（5），Re（CO）_3Cl（PhSe（CH_2）_3SePh）（6），Re（CO）_3Cl（通过Re（CO）5Cl与相应的双齿配体反应合成了HO_2C-CH_2Se（CH2）_2SeCH_2-CO_2H）（7）和Re（CO）_3Cl（HO_2C-CH_2Se（CH2）_3SeCH_2-CO_2H）（8）。。通过单晶X射线衍射分析确定5和6的结构。通过元素分析，1 H NMR，IR和质谱鉴定复合物7和8。确定了这些复合物对四种实体人类肿瘤细胞的抗增殖活性。配合物7和8的水溶性二钠盐显示出对MCF-7乳腺癌细胞的显着活性。

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2011年第2期|共7页
作者
Kermagoret A.; Morgant G.; DAngelo J.; Tomas A.; Roussel P.; Bastian G.; Collery P.; Desma?le D.;
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正文语种 eng
中图分类无机化学;
关键词
Cytotoxicity; Diseleno-ethers ligands; MTT; Rhenium(I) complexes; X-ray structures;

机译：细胞毒性;二硒醚配体;MTT;R（I）配合物;X射线结构;

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1. Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)_3Cl(PhSe(CH_2)_2SePh), Re(CO) _3Cl(PhSe(CH_2)_3SePh [J] . Kermagoret A., Morgant G., DAngelo J., Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2011,第2期

机译：四种rh（I）双硒醚复合物的几种人肿瘤细胞系的合成，结构表征和生物学活性：Re（CO）_3Cl（PhSe（CH_2）_2SePh），Re（CO）_3Cl（PhSe（CH_2）_3SePh
2. [Re(CO)3Cl(C5H4ClP)2] and [Re(CO)2Cl(C5H4ClP)3]: synthesis and characterization of two novel rhenium(i) phosphinine complexes [J] . Manuela Hollering, Richard O. Reithmeier, Simon Meister, RSC Advances . 2016,第17期

机译：[Re（CO）3Cl（C5H4ClP）2]和[Re（CO）2Cl（C 5H 4ClP）3]：两种新型铼（I）膦腈复合物的合成和表征
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Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)_3Cl(PhSe(CH_2)_2SePh), Re(CO) _3Cl(PhSe(CH_2)_3SePh

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