Reactions of N,N '-dicarboxamido-N,N '-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH4[Ru(EDTA-H)Cl

Jolley J.; Castineiras A.; Yanovsky AI.; Nolan KB.; Campbell CJ.

首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Reactions of N,N '-dicarboxamido-N,N '-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH4[Ru(EDTA-H)Cl

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Reactions of N,N '-dicarboxamido-N,N '-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH4[Ru(EDTA-H)Cl

机译：N，N′-二甲酰胺基-N，N′-二羧甲基-1，2-二氨基乙烷（EDTA-二酰胺）与水合氯化钌（III）和四氯铂酸钾（II）的反应。五齿EDTA-H配合物NH4 [Ru（EDTA-H）Cl）的晶体和分子结构

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Treatment of ruthenium (III) chloride hydrate with N,N'-dicarboxamido-N,N'-dicarboxymelhyl-1,2-diaminbethane (1) (EDTA-diamide) in refluxing HCl solution followed by cooling afforded the crystalline complex NH4[Ru(EDTA-H)Cl]. 2H(2)O (2), the EDTA-H ligand and the +NH4 cation resulting from the hydrolysis of the amide groups in 1. The crystal and molecular structure confirms that in this complex EDTA-H acts as a pentadentate ligand, bonded to the metal through the tertiary nitrogen atoms and three carboxylate oxygens. A chloride ligand completes octahedral geometry around the metal ion. Reaction of K-2[PtCl4] with the same ligand in hot basic solution followed by acidification initially gave PtCl2[HOOCCH2(2HNOCCH2)NCH2CH3 NCHCONHCOCH2]. H2O (3) which on standing gave PtCl2[(2)(HOOCCH2)NCH2CH2NCH2CONHCOCH2]. 2H(2)O (4), the crystal structure of which is also reported. This is a square planar complex of platinum(II) formed as a result of an acid-amide ring closure of ligand 1 and subsequent hydrolysis of the second amide group. The reaction of K-2[PtBr4] with 1 under similar conditions gave the complex PtBr2[HOOCCH2(2HNOCCH2)NCH2CH2NCH2CONHCOCH2]. H2O (5), The reaction of 1 with K-2[PtCl4] in neutral solution at 30 degrees C gave PtCl[OOCCH2(2HNOCCH2)NCH2CH2N(CH2CONH2)CH2COOH] (6) which was converted to PtCl2[HOOCCH2(2HNOCCH2)NCH2CH2N(CH2CONH2)CH2COOH] (7) on treatment with HCl solution. The IC50 value of complex 7 against murine P388 leukemia cells is 157 +/- 37 mu M compared to its value of 2.05 mu M for cisplatin. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 16]

机译：在回流的HCl溶液中用N，N'-二甲酰胺基-N，N'-二羧基甲硅烷基-1,2-二氨基甲酸酯（1）（EDTA-二酰胺）处理氯化钌（III）水合物，然后冷却，得到结晶配合物NH4 [Ru （EDTA-H）Cl]。 2H（2）O（2），EDTA-H配体和+ NH4阳离子由1中酰胺基的水解产生。晶体和分子结构证实，在该络合物中EDTA-H充当五齿配体，已键合通过叔氮原子和三个羧酸氧与金属结合氯化物配体完成了金属离子周围的八面体几何形状。 K-2 [PtCl4]与相同的配体在热的碱性溶液中反应，然后酸化，最初得到PtCl2 [HOOCCH2（2HNOCCH2）NCH2CH3 NCHCONHCOCH2]。静置得到PtCl2 [（2）（HOOCCH2）NCH2CH2NCH2CONHCOCH2]的H2O（3）。 2H（2）O（4），其晶体结构也有报道。这是由于配体1的酸-酰胺环封闭和随后第二酰胺基团的水解而形成的铂（II）的方形平面络合物。在类似条件下，K-2 [PtBr4]与1的反应生成了复合物PtBr2 [HOOCCH2（2HNOCCH2）NCH2CH2NCH2CONHCOCH2]。 H2O（5），1与K-2 [PtCl4]在中性溶液中于30摄氏度反应，得到PtCl [OOCCH2（2HNOCCH2）NCH2CH2N（CH2CONH2）CH2COOH]（6），将其转化为PtCl2 [HOOCCH2（2HNOCCH2）NCH2CH2N （CH2CONH2）CH2COOH]（7）用HCl溶液处理。复合物7对鼠P388白血病细胞的IC50值为157 +/-37μM，而顺铂为2.05μM。（C）1998 Elsevier ScienceLtd。保留所有权利。 [参考：16]

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《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |1998年第2期|共7页
作者
Jolley J.; Castineiras A.; Yanovsky AI.; Nolan KB.; Campbell CJ.;
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正文语种 eng
中图分类化学;无机化学;
关键词
Ruthenium(iii); Platinum(ii); Edta; Edta-amide; Complexes; Pentadentate; Ring-closure; Antitumour; Ray;

机译：钌（iii）;铂（ii）;Edta;Edta-酰胺;络合物;五齿;环闭合;抗肿瘤;射线;

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1. Reactions of N,N '-dicarboxamido-N,N '-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH4[Ru(EDTA-H)Cl [J] . Jolley J., Castineiras A., Yanovsky AI., Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 1998,第1a2期

机译：N，N′-二甲酰胺基-N，N′-二羧甲基-1，2-二氨基乙烷（EDTA-二酰胺）与水合氯化钌（III）和四氯铂酸钾（II）的反应。五齿EDTA-H配合物NH4 [Ru（EDTA-H）Cl）的晶体和分子结构
2. Syntheses, crystal structures, susceptibility and EPR studies of oxo-bridged dinuclear ruthenium (III) complexes with linear Ru-O-Ru bonds: and [(Py)_3(C_2O_4)Ru~(III)ORu~(III)(C_2O_4)(Py)_3] and [(4-MePy)_3(C_2O_4)Ru~(III)ORu~(III)(C_2O_4)(4-MePy)_3 [J] . Wen-Zhen Wang, Xin Lin, Dai-Zheng Liao, Inorganic Chemistry Communications . 2002,第11期

机译：具有线性Ru-O-Ru键的氧桥双核钌（III）配合物的合成，晶体结构，磁化率和EPR研究：和[（Py）_3（C_2O_4）Ru〜（III）ORu〜（III）（C_2O_4）（Py）_3]和[（4-MePy）_3（C_2O_4）Ru〜（III）ORu〜（III）（C_2O_4）（4-MePy）_3
3. REACTIONS OF 1,2-DIAMINOETHANE-N,N,N'N'-TETRA(N-METHYLACETAMIDE), L, WITH POTASSIUM TETRACHLOROPLATINATE(II) - CRYSTAL AND MOLECULAR STRUCTURES OF PT(LH(-2))CL-2-CENTER-DOT-2H(2)O, A NOVEL PLATINUM(IV) COMPLEX CONTAINING DEPROTONATED AMIDE LIGANDS, A [J] . Campbell CJ., Nolan KB., Castineiras A. Inorganica Chimica Acta . 1996,第2期

机译：1,2-二氨基乙烷-N，N，N'N'-四（N-甲基乙酰胺），L与四甲基戊酸钾（II）的反应-PT（LH（-2））CL-2-的晶体和分子结构CENTER-DOT-2H（2）O，一种新型的含去质子化酰胺配体的铂（IV）络合物，A
4. Synthesis and Crystal Structure of a Stable Bimetallic Neodymium (III)-Potassium Complex with the O-Benzenedisulfonate Ligand [C] . G.B.Deacon, A.Gitlits International Conference on Rare Earths . 1999

机译：稳定的双金属钕（III） - 与O-苯二硫酸盐配体络合物的合成和晶体结构
5. The structure and reactivity of a series of high-valent oxo complexes of Ru and Mn: Ru(III)-mediated catalytic oxygenation of triphenylphosphine, characterization of binuclear Mn(III,III) and Mn(III,IV) dimers, and mononuclear iron(III) and iron(IV). [D] . Fackler, Nathanael L. P. 1997

机译：Ru和Mn的一系列高价羰基配合物的结构和反应性：Ru（III）介导的三苯膦催化氧化，双核Mn（III，III）和Mn（III，IV）二聚体的表征以及单核铁（III）和铁（IV）。
6. Reaction Landscape of a Pentadentate N5-Ligated MnII Complex with O2•− and H2O2 Includes Conversion of a Peroxomanganese(III) Adduct to a Bis(μ-oxo)dimanganese(IIIIV) Species [O] . Domenick F. Leto, Swarup Chattopadhyay, Victor W. Day, -1

机译：五齿N5连接的MnII复合物与O2•-和H2O2的反应态势包括将过氧锰（III）加合物转化为双（μ-氧代）二锰（IIIIV）物种
7. Infrared spectra of the ammonium ion in crystals. Part XIII. Crystal structure of (NH4)2[AlF5(H2O)] and NH3D+ probe-ion spectra in (NH4)2[AlF5(H2O)], NH4AlF4, and (NH4)3ZnCl5, with remarks on structural filiation of AMF4 fluorides [O] . Knop, Osvald, Cameron, Stanley, Deraniyagala, S.P., 1985

机译：晶体中铵离子的红外光谱。第十三部分。（NH4）2 [AlF5（H2O）]的晶体结构和（NH4）2 [AlF5（H2O）]，NH4AlF4和（NH4）3ZnCl5中的NH3D +探针离子光谱，其中关于AMF4氟化物的结构筛选
8. The crystal and molecular structure of ruthenium-sulfur dioxide coordination compounds. i- chlorotetraammine/sulfur dioxide/-ruthenium/ii/ chloride [R] . Katz, J. L., Vogt, L. H., Jr., Wiberley, S. E. 1965

机译：钌 - 二氧化硫配位化合物的晶体和分子结构。 i-氯四胺/二氧化硫/ - 钌/ ii /氯化物

Reactions of N,N '-dicarboxamido-N,N '-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH4[Ru(EDTA-H)Cl

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