Reactions of N,N'-dicarboxamido-N,N'-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH_4[Ru(EDTA-H)Cl]

Joseph Jolley; Colm J. Campbell; Alfonso Castineiras; Alexander I. Yanovsky; Kevin B. Nolan

首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Reactions of N,N'-dicarboxamido-N,N'-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH_4[Ru(EDTA-H)Cl]

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Reactions of N,N'-dicarboxamido-N,N'-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH_4[Ru(EDTA-H)Cl]

机译：N，N'-二甲酰胺基-N，N'-二羧甲基-1,2-二氨基乙烷（EDTA-二酰胺）与水合氯化钌（III）和四氯铂酸钾（II）的反应。五齿EDTA-H配合物NH_4 [Ru（EDTA-H）Cl]的晶体和分子结构

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Treatment of ruthenium (III) chloride hydrate with N,N'-dicarboxamido-N,N'-dicarboxymethyl-1,2-diaminoethane (1) (EDTA-diamide) in refluxing HCl solution followed by cooling afforded the crystalline complex NH_4[Ru(EDTA-H)Cl] centre dot 2H_2O (2), the EDTA-H ligand and the ~+NH_4 cation resulting from the hydrolysis of the amide groups in 1. The crystal and molecular structure confirms that in this complex EDTA-H acts as a pentadentate ligand, bonded to the metal through the tertiary nitrogen atoms and three carboxylate oxygens. A chloride ligand completes octahedral geometry around the metal ion. Reaction of K_2[PtCl_4] with the same ligand in hot basic solution followed by acidification initially gave PtCl_2[HOOCCH_2(_2HNOCCH_2)NCH_2CH_2 NCHCONHCOCH_2] centre dot 2H_2O (3) which on standing gave PtCl_2[_2(HOOCCH_2)NCH_2CH_2NCH_2CONHCOCH_2] centre dot 2H_2O (4), the crystal structure of which is also reported. This is a square planar complex of platinum(II) formed as a result of an acid-amide ring closure of ligand 1 and subsequent hydrolysis of the second amide group. The reaction of K_2[PtBr_4] with 1 under similar conditions gave the complex PtBr_2[HOOCCH_2(_2HNOCCH_2)NCH_2CH_2NCH_2CONHCOCH_2] centre dot 2H_2O (5). The reaction of 1 with K_2[PtCl_4] in neutral solution at 30 deg C gave PtCl[OOCCH_2(_2HNOCCH_2)NCH_2CH_2N(CH_2CONH_2)CH_2COOH] (6) which was converted to PtCl_2[HOOCCH_2(_2HNOCCH_2)NCH_2CH_2N(CH_2CONH_2)CH_2COOH] (7) on treatment with HCl solution. The IC_(50) value of complex 7 against murine P388 leukemia cells is 157 +- 37 #mu#M compared to its value of 2.05 #mu#M for cisplatin.

机译：在回流的HCl溶液中用N，N'-二甲酰胺基-N，N'-二羧甲基-1,2-二氨基乙烷（1）（EDTA-二酰胺）处理氯化钌（III）水合物，然后冷却，得到结晶配合物NH_4 [Ru （EDTA-H）Cl]中心点2H_2O（2），EDTA-H配体和〜1酰胺基水解产生的〜+ NH_4阳离子。晶体和分子结构证实了这种复杂的EDTA-H的作用作为五齿配体，通过叔氮原子和三个羧酸氧键与金属键合。氯化物配体完成了金属离子周围的八面体几何形状。 K_2 [PtCl_4]与相同的配体在热碱性溶液中反应，然后酸化，最初得到PtCl_2 [HOOCCH_2（_2HNOCCH_2）NCH_2CH_2 NCHCONHCOCH_2]中心点2H_2O（3），静置后得到PtCl_2 [_2（HOOCCH_2）NCH_2CH_2NCH_2CONHCOCH_2]（2点） 4），也报道了其晶体结构。这是由于配体1的酸-酰胺环封闭和随后第二酰胺基团的水解而形成的铂（II）的方形平面络合物。在相似条件下，K_2 [PtBr_4]与1的反应生成了复合物PtBr_2 [HOOCCH_2（_2HNOCCH_2）NCH_2CH_2NCH_2CONHCOCH_2]中心点2H_2O（5）。 1与K_2 [PtCl_4]在中性溶液中于30℃反应，得到PtCl [OOCCH_2（_2HNOCCH_2）NCH_2CH_2N（CH_2CONH_2）CH_2COOH]（6）转化为PtCl_2 [HOOCCH_2（_2HNOCCH_2）NCH_2CH_2N（CH_2CONH_2）CH_2 ）用HCl溶液处理。复合物7对鼠P388白血病细胞的IC_（50）值为157±37＃mu＃M，而其顺铂为2.05＃mu＃M。

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来源
《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |1999年第2期|共7页
作者
Joseph Jolley; Colm J. Campbell; Alfonso Castineiras; Alexander I. Yanovsky; Kevin B. Nolan;
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正文语种 eng
中图分类化学;无机化学;
关键词
ruthenium(III); platinum(II); EDTA; EDTA-amide; complexes; pentadentate; ring-closure; antitumour;

机译：钌（III）;铂（II）;EDTA;EDTA-酰胺;配合物;五齿;环闭合;抗肿瘤;

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机译：N，N'-二甲酰胺基-N，N'-二羧甲基-1,2-二氨基乙烷（EDTA-二酰胺）与水合氯化钌（III）和四氯铂酸钾（II）的反应。五齿EDTA-H配合物NH_4 [Ru（EDTA-H）Cl]的晶体和分子结构
2. Syntheses, crystal structures, susceptibility and EPR studies of oxo-bridged dinuclear ruthenium (III) complexes with linear Ru-O-Ru bonds: and [(Py)_3(C_2O_4)Ru~(III)ORu~(III)(C_2O_4)(Py)_3] and [(4-MePy)_3(C_2O_4)Ru~(III)ORu~(III)(C_2O_4)(4-MePy)_3 [J] . Wen-Zhen Wang, Xin Lin, Dai-Zheng Liao, Inorganic Chemistry Communications . 2002,第11期

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Reactions of N,N'-dicarboxamido-N,N'-dicarboxymethyl-1,2-diaminoethane (EDTA-diamide) with hydrated ruthenium(III) chloride and potassium tetrachloroplatinate(II). Crystal and molecular structures of the pentadentate EDTA-H complex NH_4[Ru(EDTA-H)Cl]

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