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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Synthesis and cytotoxicity of new Pt(IV) complexes of 2,2 '-biimidazole and derivatives
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Synthesis and cytotoxicity of new Pt(IV) complexes of 2,2 '-biimidazole and derivatives

机译:2,2'-联咪唑及其衍生物的新型Pt(IV)配合物的合成和细胞毒性

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摘要

Compounds of type [PtCl4(LL)] [LL = 2,2'-biimidazole (H(2)bim); N-methyl-2,2'-biimidazole (MeHbim); N-hydroxyethyl-2,2'-biimidazole (HOEtHbim); or N,N'-dimethyl-2,2'-biimidazole (Me(2)bim)] were prepared and characterized. The structure of [PtCl4(Me(2)bim)] was determined by X-ray diffractometry. The crystal consists of discrete [PtCl4(Me(2)bim)] units in which the Pt atom is coordinated to the four Cl atoms and to the unmethylated N atoms in a distorted octahedral environment. Spectroscopic data suggest that all the other complexes have similar structures. The complexes of H(2)bim, MeHbim and Me(2)bim showed cytotoxic activity against both human ovarian carcinoma A2780 and the corresponding cisplatin-resistant line, A2780cis. (c) 2005 Elsevier Ltd. All rights reserved.
机译:[PtCl4(LL)]类型的化合物[LL = 2,2'-联咪唑(H(2)bim); N-甲基-2,2'-联咪唑(MeHbim); N-羟乙基-2,2'-联咪唑(HOEtHbim);或表征N,N'-二甲基-2,2'-联咪唑(Me(2)bim)]。 [PtCl4(Me(2)bim)]的结构通过X射线衍射测定。晶体由离散的[PtCl4(Me(2)bim)]单元组成,其中Pt原子在扭曲的八面体环境中与四个Cl原子和未甲基化的N原子配位。光谱数据表明所有其他复合物具有相似的结构。 H(2)bim,MeHbim和Me(2)bim的复合物显示出对人卵巢癌A2780和相应的顺铂耐药株A2780cis的细胞毒活性。 (c)2005 Elsevier Ltd.保留所有权利。

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