...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polymers for advanced technologies >Polyanhydrides with hydrophobic terminals
【24h】

Polyanhydrides with hydrophobic terminals

机译：带疏水末端的聚酸酐

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polyanhydrides prepared from hydrophobic diacids such as sebacic acid (SA) are brittle and unstable in storage and degrade with time. The physical properties of these polyanhydrides have been improved by introducing hydrophobic terminals into the main chain which has provided better stability and controlled the molecular weight. The effects of molecular weight, pliability, biodegradation and drug release on polymer were investigated. Poly(sebacic anhydride) (PSA) was terminated with the unsaturated fatty acids, ricinoleic acid, oleic acid, linoleic acid and the cholesterol derivative, lithocholic acid, and prepared in the weight ratio of 70:30. Polymers thus obtained had a predictable molecular weight of 3-8×10{sup}3 and an M{sub}p of 60-76℃ and degraded at the rate of 3.3-7.6 mg/cm{sup}2/day. The rate of degradation was dependent on the contents of the hydrophobic terminals. These polyanhydrides were found to be useful for the release of hydrophobic and hydrophilic drugs for 2-3 weeks in vitro.
机译：由疏水性二酸如癸二酸（SA）制备的聚酐易碎，储存不稳定，并随时间降解。通过将疏水性末端引入主链可改善这些聚酸酐的物理性能，该主链提供了更好的稳定性并控制了分子量。研究了分子量，柔韧性，生物降解和药物释放对聚合物的影响。用不饱和脂肪酸，蓖麻油酸，油酸，亚油酸和胆固醇衍生物石胆酸终止聚（癸二酸酐）（PSA），并以70∶30的重量比制备。如此获得的聚合物具有3-8×10 {sup} 3的可预测分子量和60-76℃的M {sub} p，并且以3.3-7.6mg / cm {sup} 2 /天的速率降解。降解速率取决于疏水性末端的含量。发现这些聚酐可用于在2-3周内释放疏水性和亲水性药物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号