Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets

Yuling Xiao; Shucai Liang; Guofu Qiu; Jianyuan Wu; Junbo Zhang; Xianming Hu

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Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets

机译：两种新型基于帕奇曼的药物辅助剂的制备，表征和压片特性：I.可分散片剂中的崩解剂

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Linear pachyman was isolated from the sclerotium of Poria cocos. Its hydroxypropyl and carboxymethyl derivatives, with considerable hydrophilicities, were synthesized. Their chemical structures, biocompatibilities, powder and tableting properties were determined. To exploit their novel applications in tablet excipients, ampicillin and probenecid dispersible tablets were compressed using the two derivatives as disintegrants, respectively. The detailed characterization of the tablets indicated the great potential of the two synthesized derivatives to be used as pharmaceutical excipients.

机译：从Por的菌核中分离出线性的食人鱼。合成了具有明显亲水性的羟丙基和羧甲基衍生物。测定了它们的化学结构，生物相容性，粉末和压片性质。为了利用其在片剂赋形剂中的新应用，分别使用两种衍生物作为崩解剂对氨苄青霉素和丙磺舒分散片进行压片。片剂的详细表征表明两种合成衍生物可用作药物赋形剂的巨大潜力。

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来源
《Polymers for advanced technologies》 |2007年第4期|共7页
作者
Yuling Xiao; Shucai Liang; Guofu Qiu; Jianyuan Wu; Junbo Zhang; Xianming Hu;
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正文语种 eng
中图分类高分子化学（高聚物）;
关键词
Linear; Pachyman derivatives; Hydrophilic polymers; Disintegrant; Biocompatibility;

机译：线性;Pachyman衍生物;亲水性聚合物;崩解剂;生物相容性;

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1. Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets [J] . Yuling Xiao, Shucai Liang, Guofu Qiu, Polymers for advanced technologies . 2007,第4期

机译：两种新型基于帕奇曼的药物辅助剂的制备，表征和压片特性：I.可分散片剂中的崩解剂
2. Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible tablets [J] . StirnimannT., DiMaiutaN., GerardD.E., Pharmaceutical research . 2013,第7期

机译：功能化碳酸钙作为制备口服分散片的新型药物赋形剂
3. Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs [J] . Yuling Xiao, Wenjin Xu, Qifeng Zhu Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2009,第3期

机译：新型基于帕奇曼的药物助剂的制备和表征。 II：pH敏感，可生物降解和生物相容的水凝胶，可控制蛋白质药物的释放
4. Preparation and characterization of myricetin dispersible tablets [C] . Erming XU, rnHan ZHANG Novel Drug Delivery Systems: Research and Application . 2007

机译：杨梅素分散片的制备与表征
5. Preparation, characterization and tableting properties of cellulose II powders [D] . Reus Medina, Maria de la Luz 2005

机译：纤维素II粉末的制备，表征和压片性能
6. The Effect of Microcrystalline Cellulose Crystallinity on the Hydrophilic Property of Tablets and the Hydrolysis of Acetylsalicylic Acid as Active Pharmaceutical Ingredient Inside Tablets [O] . Kimie Awa, Hideyuki Shinzawa, Yukihiro Ozaki 2015

机译：微晶纤维素结晶度对片剂亲水性的影响以及乙酰水杨酸作为片剂中的活性药物成分的水解作用
7. Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets [O] . Stirnimann, Tanja, Di Maiuta, Nicola, Gerard, Daniel E., 2013

机译：功能化碳酸钙作为一种新型药物辅料，用于制备口服分散片剂

Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets

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