...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polymers for advanced technologies >Synthesis of hydrophilic microspheres with LCST close to body temperature for controlled dual-sensitive drug release
【24h】

Synthesis of hydrophilic microspheres with LCST close to body temperature for controlled dual-sensitive drug release

机译：LCST接近体温的亲水性微球的合成，可控制双敏感药物的释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Novel stimuli-responsive hydrophilic microspheres were prepared by free radical polymerization of hydroxyethyl methacrylate (HEMA) and methacrylic acid (MA), as hydrophilic monomers, and N-isopropylacrylamide (NIPAAm) and N,N'-ethylenebisacrylamide (EBA), as thermo-sensitive monomer and crosslinker, respectively. Hydrophilic comonomers were introduced in the macromolecular network to synthesize materials with tunable thermal behavior. In addition, by introducing in the polymerization feed both a hydrophilic and a pH-sensitive monomer, such as MA, dual stimuli-responsive (pH and temperature) hydrogels were synthesized. The incorporation of monomers in the network was confirmed by infrared spectroscopy, while the network density and the shape of hydrogels was found to strictly depend on the concentration of monomers in the polymerization feed. Thermal analyses showed negative thermo responsive behavior with pronounced water affinity of microspheres at a temperature lower than lower critical solution temperature (LCST). In our experiment, the LCST values of the hydrogels were in the range 34.6-37.5℃, close to the body temperature, and the amount of hydrophilic moieties in the polymeric network allows to collect shrinking/swelling transition temperatures higher than the LCST of NIPAAm homopolymers. In order to test the preformed materials as drug carriers, diclofenac diethylammonium salt (DDA) was chosen and drug entrapment percent was determined. Drug release profiles, in media at different temperature and pH, depend on hydrogels crosslinking degree and drug-bead interactions. By using semi-empirical equations, the release mechanism was extensively studied and the diffusional contribute was evaluated.
机译：通过甲基丙烯酸羟乙酯（HEMA）和甲基丙烯酸（MA）作为亲水性单体，以及N-异丙基丙烯酰胺（NIPAAm）和N，N'-亚乙基双丙烯酰胺（EBA）的自由基聚合反应制备新型的刺激响应性亲水性微球。敏感单体和交联剂。将亲水性共聚单体引入大分子网络，以合成具有可调热行为的材料。另外，通过在聚合进料中引入亲水性单体和对pH敏感的单体（例如MA），合成了双重刺激响应（pH和温度）水凝胶。通过红外光谱证实了单体在网络中的掺入，而发现网络密度和水凝胶的形状严格取决于聚合进料中单体的浓度。热分析表明，在低于较低的临界溶液温度（LCST）的温度下，微球具有明显的水亲合力，具有负的热响应行为。在我们的实验中，水凝胶的LCST值在34.6-37.5℃的范围内，接近于体温，并且聚合物网络中亲水部分的数量允许收集的收缩/溶胀转变温度高于NIPAAm均聚物的LCST。 。为了测试作为药物载体的预制材料，选择了双氯芬酸二乙铵盐（DDA）并确定了药物截留率。在不同温度和pH值的介质中，药物释放曲线取决于水凝胶的交联度和药物-珠相互作用。通过使用半经验方程，对释放机理进行了广泛研究，并评估了扩散贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号