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Selective analysis of phenolic compounds in propolis by HPLC-MS/MS

机译：HPLC-MS / MS对蜂胶中酚类化合物的选择性分析

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Phenolic compounds (flavonoids and phenolic acid derivatives) are major active constituents of the resinous fraction of propolis, and also represent its allergenic principles. We have developed a chromatography electrospray ionisation tandem mass spectrometry (HPLC-ESI-MS/MS) method to characterise the polyphenolic fraction of propolis rapidly and quali-quantitatively. With precursor ion scanning, selective detection of caffeic esters was easily achieved, confirming the identification of prenyl caffeate, benzyl caffeate and phenylethyl caffeate by comparison with synthetic standards. The ionisation and fragmentation behaviour of the major propolis flavonoids was rationalised and applied to selected real samples. Taken together, the results of this study show that the introduction of precursor ion analysis leads to a significant improvement in the characterisation of the phenolic fraction of propolis, paving the way to the establishment of a better quality control for this important natural remedy. Copyright pb 2007 John Wiley & Sons, Ltd.
机译：酚类化合物（类黄酮和酚酸衍生物）是蜂胶树脂级分的主要活性成分，也代表了其致敏原理。我们已经开发了一种色谱电喷雾电离串联质谱法（HPLC-ESI-MS / MS），以快速，定性地表征蜂胶的多酚部分。通过前体离子扫描，可以轻松实现对咖啡酸酯的选择性检测，从而通过与合成标准品的比较确认了异戊烯基咖啡酸酯，苄基咖啡酸酯和苯乙基咖啡酸酯的鉴定。主要蜂胶类黄酮的离子化和裂解行为已合理化，并应用于选定的实际样品。两者合计，这项研究的结果表明，前体离子分析的引入大大改善了蜂胶酚类成分的表征，为建立针对这一重要天然药物的更好质量控制铺平了道路。版权所有pb 2007 John Wiley＆Sons，Ltd.

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