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Synthesis and characterization of amphiphilic antibacterial copolymers

机译：两亲性抗菌共聚物的合成与表征

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摘要

Macromolecule antimicrobials have been explored in foundational research and practical application due to their potential merit for reducing the residual toxicity, increasing their efficiency, selectivity, and prolonging the lifetime of the antimicrobial material. In this work, the quaternized poly(styrene)-b-poly(DMAEMA) diblock polymers are synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT). The minimum inhibitory concentration (MIC) evaluation and optical density (OD) method demonstrated that the amphiphilic antibacterial biomaterials have exceptional antibacterial properties. The amphiphilic polycation has an admirable antibacterial property, and these quaternized diblocks are potent biocides and nonhemolytic. The relationship between the structure and activity is discussed with respect to molecular weight of the diblocks and bacteria structural dependence.
机译：由于高分子抗微生物剂具有减少残留毒性，提高其效率，选择性和延长抗微生物材料寿命的潜在优点，因此已在基础研究和实际应用中进行了探索。在这项工作中，季铵化的聚（苯乙烯）-b-聚（DMAEMA）双嵌段聚合物是通过可逆的加成-断裂链转移聚合（RAFT）合成的。最小抑菌浓度（MIC）评估和光密度（OD）方法表明，两亲性抗菌生物材料具有出色的抗菌性能。两亲性聚阳离子具有令人钦佩的抗菌性能，这些季铵化的二嵌段是有效的杀菌剂，且不溶血。关于二嵌段的分子量和细菌的结构依赖性，讨论了结构和活性之间的关系。

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