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Enzymatically controlled responsive drug delivery systems

机译：酶控响应药物递送系统

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摘要

This paper discusses two approaches for the preparation of enzymatically controlled drug delivery systems: (i) a calcium-responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, α-amylase, in its non-active form; (ii) a glucose-responsive insulin delivery system based on the hydrogel poly(2-hydroxyethyl methacrylate-co-NN-di methylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity to a trigger molecule (calcium or glucose) was achieved by the incorporation of a specific enzyme that reacts with the trigger molecule. Based on these interactions we propose two different enzyme-controlled drug release mechanisms for responsive drug delivery systems.
机译：本文讨论了两种制备酶控制药物递送系统的方法：（i）基于淀粉与HPMC（羟丙基甲基纤维素醚）（可生物降解）和淀粉水解酶α的混合物的钙反应性生物可降解药物递送系统-非活性形式的淀粉酶; （ii）基于水凝胶聚（甲基丙烯酸2-羟乙酯-共-NN-二甲基氨基乙基甲基丙烯酸酯）的水凝胶，其中包埋有葡萄糖氧化酶，过氧化氢酶和胰岛素。在这两个系统中，对触发分子（钙或葡萄糖）的敏感性是通过掺入与触发分子反应的特定酶来实现的。基于这些相互作用，我们提出了两种不同的酶控制药物释放机制，用于响应性药物递送系统。

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