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首页> 外文期刊>Polymers for advanced technologies >Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite
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Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

机译：用于控制异烟肼传递的羧甲基壳聚糖-蒙脱土纳米颗粒：评估戊二醛和蒙脱石的作用

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摘要

Chitosan, a natural biopolymer, is used for drug delivery application. But its potential application is limited by its low solubility in aqueous media. The present study was designed to prepare carboxymethyl chitosan (CMC), a water soluble derivative of chitosan, and evaluate the prospective of crosslinked CMC-Montmorillonite (MMT) nanoparticles for controlled delivery of isoniazid. The nanoparticles were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Transmission emission microscopy (TEM). The effects of MMT and glutaraldehyde on nanoparticles were assessed with regard to encapsulation efficiency, percentage swelling degree, and cumulative release. Percentage swelling degree and cumulative release were studied in pH medium 1.2 and 7.4 for 6 h. The cumulative release was studied by UV-visible spectrophotometer. Cell viability study was performed by MTT assay analysis. FTIR and NMR study indicated the successful preparation of CMC. FTIR study confirmed the interaction of MMT with CMC. The exfoliation of MMT layers and molecular level dispersion of isoniazid in CMC was examined by XRD and TEM. SEM study showed that the surface of the CMC-MMT nanoparticles was smooth compared with those of CMC nanoparticles. Swelling and release of isoniazid from the nanoparticles increased with the decrease in the MMT and glutaraldehyde content. The percentage swelling degree and cumulative release was more in pH 1.2. Cell viability study revealed that CMC was not cytotoxic, and the nanoparticles containing MMT was less cytotoxic than those of MMT free nanoparticles. CMC-MMT nanoparticles can be exploited as potential drug carrier for controlled release applications.
机译：壳聚糖是一种天然生物聚合物，可用于药物输送。但是其潜在的应用受到其在水性介质中低溶解度的限制。本研究旨在制备羧甲基壳聚糖（CMC），一种壳聚糖的水溶性衍生物，并评估交联CMC-蒙脱土（MMT）纳米粒用于异烟肼可控递送的前景。纳米粒子的特征在于傅立叶透射红外光谱（FTIR），核磁共振（NMR），X射线衍射（XRD），扫描电子显微镜（SEM）和透射发射显微镜（TEM）。关于包封效率，溶胀度百分数和累积释放，评估了MMT和戊二醛对纳米颗粒的影响。在pH介质1.2和7.4中研究溶胀度和累积释放百分率6h。用紫外可见分光光度计研究累积释放。通过MTT测定分析进行细胞活力研究。 FTIR和NMR研究表明CMC的成功制备。 FTIR研究证实了MMT与CMC的相互作用。用XRD和TEM观察了异烟肼在CMC中MMT层的剥离和分子水平的分散。 SEM研究表明，与CMC纳米颗粒相比，CMC-MMT纳米颗粒的表面光滑。随着MMT和戊二醛含量的降低，异烟肼从纳米颗粒的溶胀和释放增加。在pH 1.2下，溶胀度和累积释放百分率更高。细胞活力研究表明，CMC没有细胞毒性，并且含有MMT的纳米颗粒比不含MMT的纳米颗粒具有更低的细胞毒性。 CMC-MMT纳米粒子可以用作控释应用的潜在药物载体。

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