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首页> 外文期刊>Polymers for advanced technologies >Synthesis and characterization of macroinitiator-amino terminated PEG and poly(γ-benzyl-L-glutamate)-PEO-poly(γ-benzyl-L-glutamate) triblock copolymer
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Synthesis and characterization of macroinitiator-amino terminated PEG and poly(γ-benzyl-L-glutamate)-PEO-poly(γ-benzyl-L-glutamate) triblock copolymer

机译：大分子引发剂-氨基封端的PEG和聚（γ-苄基-L-谷氨酸）-PEO-聚（γ-苄基-L-谷氨酸）三嵌段共聚物的合成与表征

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摘要

Macroinitiator-amino terminated poly(ethylene glycol) (PEG) (NH{sub}2-PEO-NH{sub}2) was prepared by converting both terminal hydroxyl groups of PEG to more reactive primary amino groups. The synthetic route involved reactions of chloridize, phthalimide and finally hydrazinolysis. Furthermore, poly(γ-benzyl-L-glutamate)-poly(ethylene oxide)-poly(γ-benzyl-L-glutamate) (PBLG-PEO-PBLG) triblock copolymer was synthesized by polymerization of γ-benzyl-L-glutamate N-carboxyanhydride (Bz-L-GluNCA) using NH{sub}2-PEO-NH{sub}2 as macroinitiator. The resultant NH{sub}2-PEO-NH{sub}2 and triblock copolymer were characterized by FT-IR, 1{sup left}H-NMR and gel permeation chromatography (GPC) techniques. The results demonstrated that the degree of amination of the NH{sub}2-PEO-NH{sub}2 could be up to 1.95. The molecular weight of the PBLG-PEO-PBLG triblock copolymer could be adjusted easily by controlling the molar ratio of Bz-L-Glu NCA to the macroinitiator NH{sub}2-PEO-NH{sub}2.
机译：通过将PEG的两个末端羟基均转化为反应性更高的伯氨基来制备大分子引发剂-氨基末端的聚乙二醇（PEG）（NH {sub} 2-PEO-NH {sub} 2）。合成路线涉及氯化，邻苯二甲酰亚胺和最后的肼解反应。此外，通过聚合γ-苄基-L-谷氨酸，合成了聚（γ-苄基-L-谷氨酸）-聚（环氧乙烷）-聚（γ-苄基-L-谷氨酸）（PBLG-PEO-PBLG）三嵌段共聚物。使用NH {sub} 2-PEO-NH {sub} 2作为大分子引发剂的N-羧基酐（Bz-L-GluNCA）。所得的NH {sub} 2-PEO-NH {sub} 2和三嵌段共聚物通过FT-IR，1 H-NMR和凝胶渗透色谱法（GPC）表征。结果表明，NH {sub} 2-PEO-NH {sub} 2的胺化度可以达到1.95。通过控制Bz-L-Glu NCA与大分子引发剂NH {sub} 2-PEO-NH {sub} 2的摩尔比，可以容易地调节PBLG-PEO-PBLG三嵌段共聚物的分子量。

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