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首页> 外文期刊>Polymers for advanced technologies >Synthesis, structural and mechanical properties of porous polymeric scaffolds for bone tissue regeneration based on neat poly(ε-caprolactone) and its composites with calcium carbonate
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Synthesis, structural and mechanical properties of porous polymeric scaffolds for bone tissue regeneration based on neat poly(ε-caprolactone) and its composites with calcium carbonate

机译：纯聚（ε-己内酯）及其碳酸钙复合材料用于骨组织再生的多孔聚合物支架的合成，结构和力学性能

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The aim of the present study was to develop new materials which could be applicable as bone substitutes or be used in bone tissue engineering. Two types of porous scaffolds based on poly(ε-caprolactone) (PCL) were investigated. Type 1 scaffolds were prepared by solvent casting/particulate leaching technique, using NaCl with the grain size 250-500μm as a porogen. In the case of Type 2 scaffolds, the biodegradable polymer was blended with calcium carbonate, which, in contrast to NaCl, is not leached out from the product during manufacture, either in the form of calcite powder or aragonite (needle-like crystals). Influence of manufacturing technique and initial substrate composition on product properties was investigated. The tests involved porosity measurements, structure analysis by optical and scanning electron microscopy and mechanical studies (determination of compression strength and modulus). The results indicate the important role of the phase exchange process in the formation of micropores. In this process PCL precipitated from its acetone solution in the presence of water creating microporous three-dimensional polymer structures. The Type 1 scaffolds possessed both micropores and macropores. Good interconnectivity between the pores was observed for samples of the initial porogen content higher than 33%. Microporous samples containing inorganic filler have lower porosity and higher compression strength. For Type 2 scaffolds the shape of filler particles has an important influence on mechanical properties-replacing powder with needle-like crystals (in the same weight amount) results in a three- to five-fold increase in compression modulus.
机译：本研究的目的是开发可以用作骨替代物或用于骨组织工程的新材料。研究了两种基于聚ε-己内酯（PCL）的多孔支架。通过溶剂浇铸/微粒浸出技术，使用粒径为250-500μm的NaCl作为致孔剂，制备1型支架。对于2型支架，将可生物降解的聚合物与碳酸钙混合，与NaCl相比，碳酸钙在生产过程中不会以方解石粉或文石的形式从产品中浸出（针状晶体）。研究了制造技术和初始基材组成对产品性能的影响。这些测试包括孔隙率测量，通过光学和扫描电子显微镜进行的结构分析以及机械研究（确定抗压强度和模量）。结果表明相交换过程在微孔形成中的重要作用。在此过程中，PCL在水的存在下从其丙酮溶液中沉淀出来，从而形成微孔三维聚合物结构。 1型支架同时具有微孔和大孔。对于初始成孔剂含量高于33％的样品，孔之间具有良好的互连性。含有无机填料的微孔样品具有较低的孔隙率和较高的压缩强度。对于2型脚手架，填料颗粒的形状对机械性能具有重要影响-用针状晶体代替粉末（重量相同）会导致压缩模量增加三到五倍。

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