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Biopolymer-hydroxyapatite composite coatings prepared by electrospinning

机译:电纺丝制备的生物聚合物-羟基磷灰石复合涂料

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摘要

Biocompatibility in research and development of advanced prosthetics is a current problem faced by medical researchers. Hydroxyapatite (HA) is a natural ceramic (responsible for strength and stability in the human skeletal system) operable as a biocomposite coating to improve the biocompatibility of materials such as silicon nitride, typically used for bone replacement. In this study, polymer based composites were prepared by electrospinning HA with a biocompatible polymer for the development of a structurally stable casing for prosthetic devices. Presented in this paper is the morphological and structural study of electrospun polymer-HA mats. Electrospun mats were calcinated at the phase transformation temperature of HA revealing pure HA wires with diameters just under 1μm and lengths of the order of 10 to 50μm. Results have outlined the dispersion mechanism of HA electrospun with polyvinylpyrrolidone (PVP) and cellulose acetate (CA) in varying solvents to discern the effects of acidic additives and electrospinning on the production of HA wires.
机译:在高级假体的研发中,生物相容性是医学研究人员面临的当前问题。羟基磷灰石(HA)是一种天然陶瓷(负责人体骨骼系统的强度和稳定性),可作为生物复合材料涂层来改善通常用于骨骼置换的材料(如氮化硅)的生物相容性。在这项研究中,通过将HA与生物相容性聚合物静电纺丝来制备基于聚合物的复合材料,以开发用于假体装置的结构稳定的外壳。本文介绍的是电纺聚合物-HA毡的形态和结构研究。在HA的相变温度下对电纺垫进行煅烧,露出直径仅在1μm以下且长度在10至50μm左右的纯HA线。结果概述了聚乙烯吡咯烷酮(PVP)和醋酸纤维素(CA)在不同溶剂中的静电纺丝HA的分散机理,以识别酸性添加剂和静电纺丝对HA线材生产的影响。

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