• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polymers for advanced technologies >Bioactive polyurethanes in clinical applications
【24h】

Bioactive polyurethanes in clinical applications

机译：临床应用中的生物活性聚氨酯

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biomaterials play an important role in most tissue engineering strategies. They can serve as substrates on which cell populations can attach and migrate, can be used as cell delivery vehicles and as bioactive factor carriers to activate specific cellular functions. A series of biodegradable polyurethanes (PUs) with tunable chemical, physical and degradation properties, showing an adequate response to in vitro tests was proposed for applications in soft tissue engineering. Three-dimensional scaffolds of superimposed square meshed grids were prepared by using a rapid prototyping technique (pressure activated microsyringe, PAM) and tested in vivo. Functionalization of PU systems was performed in order to control the chemistry of the materials for the promotion of highly specific binding interactions between materials and biological environments. Two different approaches were used for the coupling of bioactive molecules such as gelatin. The first involved the modification of the polymer chain through a novel monomer and the second one consisted in a surface modification by plasma-induced graft copolymerization of acrylic acid.
机译：生物材料在大多数组织工程策略中起着重要作用。它们可以用作细胞群体可以附着和迁移的底物，可以用作细胞递送载体和生物活性因子载体，以激活特定的细胞功能。提出了一系列具有可调节的化学，物理和降解特性的生物可降解聚氨酯（PU），它们对软组织工程的应用显示出对体外测试的充分响应。通过使用快速原型技术（压力激活微注射器，PAM）制备叠加的方形网状网格的三维支架，并在体内进行测试。为了控制材料的化学性质以促进材料与生物环境之间的高度特异性结合相互作用，进行了PU系统的功能化。两种不同的方法用于偶联生物活性分子（例如明胶）。第一个涉及通过新型单体对聚合物链的改性，第二个涉及通过等离子体诱导的丙烯酸接枝共聚进行的表面改性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号