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首页> 外文期刊>Polymers for advanced technologies >Fabrication and properties of mineralized collagen-chitosan/hydroxyapatite scaffolds
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Fabrication and properties of mineralized collagen-chitosan/hydroxyapatite scaffolds

机译：矿化胶原壳聚糖/羟基磷灰石支架的制备与性能

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摘要

A hydroxyapatite (HAp)/biopolymer composite scaffold was fabricated by mineralizing a cross-linked collagen/chitosan, which was pre-mineralized with Ca{sup}(2+) and phosphate salts, in simulated body fluid (SBF) for only 24 hr. A self-organized structure similar to bone is expected. Microstructures of the crosslinked collagen/chitosan scaffold, the pre-mineralized collagen-chitosan scaffold (CCS), and the mineralized collagen-chitosan/HAp scaffolds (MCCHS) were characterized by scanning electron microscopy (SEM), revealing non-alteration of the porous structure and formation of the HAp particles. X-ray diffractometer (XRD) confirmed the crystalline structure of the HAp. Thermal gravimetric analysis found that more HAp particles were formed when the CCSs were pre-mineralized in a higher concentration of Ca{sup}(2+). Water-uptake ratio of the crosslinked CCS was ～160, decreased to ～120 after incubating in Ca{sup}(2+) solution, and further decreased to ～20 after mineralization. Mechanical strength of the CCS was improved significantly after the in situ mineralization too. The method introduced here may be potentially applied to obtain other biopolymer/HAp composite in a short period.
机译：羟基磷灰石（HAp）/生物聚合物复合支架是通过将交联的胶原蛋白/壳聚糖矿化，并在模拟体液（SBF）中仅用Ca {sup}（2+）和磷酸盐盐进行预矿化而制造的，仅需24小时。预计会出现类似于骨骼的自组织结构。通过扫描电子显微镜（SEM）对交联的胶原/壳聚糖支架，矿化前的胶原-壳聚糖支架（CCS）和矿化的胶原-壳聚糖/ HAp支架（MCCHS）的微观结构进行了表征，揭示了多孔性没有改变HAp颗粒的结构和形成。 X射线衍射仪（XRD）证实了HAp的晶体结构。热重分析发现，当CCSs在较高浓度的Ca {sup}（2+）中预矿化时，会形成更多的HAp颗粒。交联CCS的吸水率约为160，在Ca {sup}（2+）溶液中孵育后降低至〜120，矿化后进一步降低至〜20。原位矿化后，CCS的机械强度也大大提高。本文介绍的方法可能有可能在短时间内用于获得其他生物聚合物/ HAp复合材料。

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