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Thermogelation of amphiphilic poly(asparagine) derivatives

机译：两亲性聚天冬酰胺衍生物的热凝胶化

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Thermoresponsive sol-gel transition polymers based on biodegradable poly(amino acid) were synthesized by the reaction of poly(succinimide) with dodecylamine and amino alcohols. The introduction of the hydrophobic amine into the thermoresponsive poly(amino acid)s induced the sol-gel transition in phosphate buffer saline. The effects of the side chain structure, molecular weight, concentration of the polymer, and the additives (inorganic salts and urea) in the solution on the thermoresponsive behaviors were systematically investigated. A relationship between the lowest critical solution temperature (LCST) in the dilute solution and the viscosity reduction of the concentrated solution upon heating was observed. The present poly(amino acid)s showing a thermoresponsive sol-gel transition in aqueous solutions possess immense potential as an injectable biodegradable hydrogel system for various biomedical applications.
机译：通过聚琥珀酰亚胺与十二烷基胺和氨基醇的反应合成了基于生物可降解聚氨基酸的热敏性溶胶-凝胶转变聚合物。将疏水性胺引入到热响应性聚氨基酸中可诱导磷酸盐缓冲液中的溶胶-凝胶转变。系统研究了侧链结构，分子量，聚合物浓度以及溶液中添加剂（无机盐和尿素）对热响应行为的影响。观察到稀溶液中的最低临界溶液温度（LCST）与浓缩溶液在加热时的粘度降低之间的关系。在水溶液中显示出热响应性溶胶-凝胶转变的本发明的聚（氨基酸）具有作为用于各种生物医学应用的可注射的可生物降解的水凝胶体系的巨大潜力。

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