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Synthesis and characterization of pH-sensitive PAMPS/PVP nanogels in aqueous media

机译：在水介质中pH敏感的PAMPS / PVP纳米凝胶的合成与表征

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摘要

A novel method for preparing poly (2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) and poly (vinylpyrrolidone) (PVP) complex nanogels in PVP aqueous solution is discussed in this paper. The PAMPS/PVP complex nanogels were prepared via polymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) monomer in the presence of PVP nanoparticles which formed in water/acetone cosolvent in presence of N, N'-methylenebisacrylamide (MBA) as a crosslinker, N, N, N', N'-tetramethylethylenediamine (TEMED) and potassium peroxydisulfate (KPS) as redox initiator system. The results of FTIR and ~1H NMR spectra indicated that the compositions of PAMPS/PVP are consistent with the designed structure. TEM micrographs proved that PAMPS/PVP nanogels possess the spherical morphology before and after swelling. These PAMPS/PVP nanogels exhibited pH-induced phase transition due to protonation of PAMPS chains. The properties of PAMPS/PVP nanogels indicate that PAMPS/PVP nanogels can be developed into a pH-controlled drug delivery system.
机译：本文讨论了一种在PVP水溶液中制备聚（2-丙烯酰胺基-2-甲基丙烷磺酸）（PAMPS）和聚（乙烯基吡咯烷酮）（PVP）复合纳米凝胶的新方法。 PAMPS / PVP复合纳米凝胶是在PVP纳米粒子存在下通过2-丙烯酰胺基-2-甲基丙烷磺酸（AMPS）单体的聚合制备的，该PVP纳米粒子在水/丙酮助溶剂中在N，N'-亚甲基双丙烯酰胺（MBA）的存在下形成。交联剂N，N，N'，N'-四甲基乙二胺（TEMED）和过氧化二硫酸钾（KPS）作为氧化还原引发剂体系。 FTIR和〜1H NMR谱图的结果表明，PAMPS / PVP的组成与设计结构一致。 TEM显微照片证明，PAMPS / PVP纳米凝胶在溶胀前后具有球形形态。这些PAMPS / PVP纳米凝胶由于PAMPS链的质子化而表现出pH诱导的相变。 PAMPS / PVP纳米凝胶的性质表明，PAMPS / PVP纳米凝胶可发展为pH值控制的药物递送系统。

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